Van Cong N, Vaisse C, Gross M S, Slim R, Milgrom E, Bernheim A
Laboratoire de Cytogénétique et de Génétique Oncologiques, UA 1158 CNRS, Institut Gustave Roussy, Villejuif, France.
Hum Genet. 1991 Mar;86(5):515-8. doi: 10.1007/BF00194645.
PP14 protein (placental protein 14) is abundantly secreted by the human endometrium under the influence of progesterone. Human PP14 is homologous to beta-lactoglobulin, the main component of equine, bovine, and ovine milk whey. A genomic PP14 probe (PP14G1) was used for the chromosome assignment of the PP14 gene. Somatic hybrid cells enabled PP14G1 to be assigned to chromosome 9. In situ hybridization further refined this assignment to 9q34. The localization of the PP14 gene in the region of the ABO locus is consistent with the linkage described in bovines between beta-lactoglobulin and the J blood group (homologous to the human ABO group).
PP14蛋白(胎盘蛋白14)在孕酮的影响下由人子宫内膜大量分泌。人PP14与β-乳球蛋白同源,β-乳球蛋白是马、牛和羊乳清的主要成分。一个基因组PP14探针(PP14G1)被用于PP14基因的染色体定位。体细胞杂交细胞使得PP14G1被定位到9号染色体。原位杂交进一步将该定位精确到9q34。PP14基因在ABO基因座区域的定位与牛中β-乳球蛋白和J血型(与人ABO血型同源)之间描述的连锁关系一致。