通过铃木-宫浦交叉偶联反应合成含硫芳基和杂芳基乙烯基用于制备表面增强拉曼光谱活性聚合物
Synthesis of Sulfur-Containing Aryl and Heteroaryl Vinyls via Suzuki-Miyaura Cross-Coupling for the Preparation of SERS-Active Polymers.
作者信息
Perez-Pineiro Rolando, Dai Sheng, Alvarez-Puebla Ramon, Wigginton James, Al-Hourani Baker Jawabrah, Fenniri Hicham
机构信息
National Institute for Nanotechnology, National Research Council, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada.
出版信息
Tetrahedron Lett. 2009 Sep 30;50(39):5467-5469. doi: 10.1016/j.tetlet.2009.07.061.
Abstract
The preparation of sulfur-containing aryl and heteroaryl vinyl co-monomers via Suzuki-Miyaura cross-coupling between the corresponding mercaptomethyl arylboronates and in situ-generated vinyl bromides is described. Surface enhanced Raman scattering (SERS) studies of the target compounds on gold nanoparticles confirmed their potential as spectroscopic tags in the fabrication of SERS-encoded polymers for combinatorial screening and biomedical diagnostics.
摘要
本文描述了通过相应的巯基甲基芳基硼酸酯与原位生成的乙烯基溴之间的铃木-宫浦交叉偶联反应制备含硫芳基和杂芳基乙烯基共聚单体的方法。对金纳米颗粒上的目标化合物进行的表面增强拉曼散射（SERS）研究证实了它们在制备用于组合筛选和生物医学诊断的SERS编码聚合物时作为光谱标记物的潜力。
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