Kepler G M, Banks H T, Davidian M, Rosenberg E S
Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC 27695-8205.
Math Comput Model. 2009 Apr;49(7-8):1653-1663. doi: 10.1016/j.mcm.2008.06.003.
We propose a model for HCMV infection in healthy and immunosuppressed patients. First, we present the biological model and formulate a system of ordinary differential equations to describe the pathogenesis of primary HCMV infection in immunocompetent and immunosuppressed individuals. We then investigate how clinical data can be applied to this model. Approximate parameter values for the model are derived from data available in the literature and from mathematical and physiological considerations. Simulations with the approximated parameter values demonstrates that the model is capable of describing primary, latent, and secondary (reactivated) HCMV infection. Reactivation simulations with this model provide a window into the dynamics of HCMV infection in (D-R+) transplant situations, where latently-infected recipients (R+) receive transplant tissue from HCMV-naive donors (D-).
我们提出了一个针对健康和免疫抑制患者的人巨细胞病毒（HCMV）感染模型。首先，我们给出生物学模型并建立常微分方程组，以描述免疫功能正常和免疫抑制个体中初次HCMV感染的发病机制。然后，我们研究如何将临床数据应用于该模型。模型的近似参数值来自文献中的可用数据以及数学和生理学考量。用近似参数值进行的模拟表明，该模型能够描述初次、潜伏和二次（再激活）HCMV感染。用此模型进行的再激活模拟为（D-R+）移植情况下HCMV感染的动态变化提供了一个窗口，即潜伏感染的受者（R+）接受来自未感染HCMV的供者（D-）的移植组织。
