From EPOthilone to EPO: Aa challenge for natural product synthesis.
作者信息
Brown Zachary Z, Muir Tom W
机构信息
Frick Chemistry Laboratory, Princeton University, Princeton, NJ 08544, USA.
出版信息
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7134-5. doi: 10.1073/pnas.1205667109. Epub 2012 Apr 23.
Abstract
摘要
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本文引用的文献
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Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations.通过反复的丙氨酸连接来探测非糖基化野生型促红细胞生成素蛋白的稳定性。
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7196-201. doi: 10.1073/pnas.1202762109. Epub 2012 Apr 12.
2
Chemical synthesis of homogeneous human glycosyl-interferon-β that exhibits potent antitumor activity in vivo.体内具有强大抗肿瘤活性的均相人糖基干扰素-β的化学合成。
J Am Chem Soc. 2012 Mar 28;134(12):5428-31. doi: 10.1021/ja2109079. Epub 2012 Mar 15.
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Recent Departures in the Synthesis of Peptides and Glycopeptides.肽和糖肽合成的最新进展。
Tetrahedron. 2009 Nov 7;65(45):9047-9065. doi: 10.1016/j.tet.2009.09.032.
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Design and synthesis of a homogeneous erythropoietin analogue with two human complex-type sialyloligosaccharides: combined use of chemical and bacterial protein expression methods.具有两种人复合类型唾液酸寡糖的均一促红细胞生成素类似物的设计与合成：化学方法与细菌蛋白表达方法的联合应用
Angew Chem Int Ed Engl. 2009;48(50):9557-60. doi: 10.1002/anie.200904376.
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Semisynthesis of a homogeneous glycoprotein enzyme: ribonuclease C: part 2.一种均一糖蛋白酶的半合成：核糖核酸酶C：第2部分
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Total chemical synthesis of proteins.蛋白质的全化学合成
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Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides.基于自由基的半胱氨酸特异性脱硫：多肽和糖多肽合成中的一项重大进展。
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