Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Adv Drug Deliv Rev. 2012 May 1;64(6):496-507. doi: 10.1016/j.addr.2011.11.013. Epub 2011 Dec 4.
Micro-/nanoscale technologies such as lithographic techniques and microfluidics offer promising avenues to revolutionalize the fields of tissue engineering, drug discovery, diagnostics and personalized medicine. Microfabrication techniques are being explored for drug delivery applications due to their ability to combine several features such as precise shape and size into a single drug delivery vehicle. They also offer to create unique asymmetrical features incorporated into single or multiple reservoir systems maximizing contact area with the intestinal lining. Combined with intelligent materials, such microfabricated platforms can be designed to be bioadhesive and stimuli-responsive. Apart from drug delivery devices, microfabrication technologies offer exciting opportunities to create biomimetic gastrointestinal tract models incorporating physiological cell types, flow patterns and brush-border like structures. Here we review the recent developments in this field with a focus on the applications of microfabrication in the development of oral drug delivery devices and biomimetic gastrointestinal tract models that can be used to evaluate the drug delivery efficacy.
微纳技术，如光刻技术和微流控技术，为组织工程、药物发现、诊断和个性化医学领域带来了革命性的发展。由于微制造技术能够将精确的形状和尺寸等多种特性结合到单个药物输送载体中，因此正在探索其在药物输送中的应用。它们还能够创造独特的不对称特征，这些特征被整合到单个或多个储库系统中，从而最大限度地增加与肠衬里的接触面积。与智能材料结合使用，这些微制造平台可以设计为具有生物粘附性和刺激响应性。除了药物输送装置，微制造技术还为创建仿生胃肠道模型提供了令人兴奋的机会，这些模型包含生理细胞类型、流动模式和类似刷状缘的结构。本文重点介绍了微制造在口服药物输送装置和仿生胃肠道模型开发中的应用，这些模型可用于评估药物输送效果。
