Strand Nicholas, Bhushan Abhinav, Schivo Michael, Kenyon Nicholas J, Davis Cristina E
Mechanical and Aerospace Engineering Department, University of California, Davis, One Shields Avenue, Davis, CA 95616.
Sens Actuators B Chem. 2010 Jan 7;143(2):516-523. doi: 10.1016/j.snb.2009.09.052.
A wide range of metabolites are measured in the gas phase of exhaled human breath, and some of these biomarkers are frequently observed to be up- or down-regulated in certain disease states. Portable breath analysis systems have the potential for a wide range of applications in health diagnostics. However, this is currently limited by the lack of concentration mechanisms to enhance trace metabolites found in the breath to levels that can be adequately recorded using miniaturized gas-phase sensors. In this study we have created chip-based polymeric pre-concentration devices capable of absorbing and desorbing breath volatiles for subsequent chemical analysis. These devices appear to concentrate chemicals from both environmental air samples as well as directly from exhaled human breath, and these devices may have applications in lab-on-a-chip-based environmental and health monitoring systems.
人们对呼出气体气相中的多种代谢物进行了测量，并且经常观察到其中一些生物标志物在某些疾病状态下会上调或下调。便携式呼吸分析系统在健康诊断方面具有广泛的应用潜力。然而，目前这受到缺乏浓缩机制的限制，无法将呼出气体中发现的痕量代谢物提高到能够使用小型化气相传感器进行充分记录的水平。在本研究中，我们制造了基于芯片的聚合物预浓缩装置，该装置能够吸收和解吸呼吸挥发性物质，以便进行后续化学分析。这些装置似乎能够从环境空气样本以及直接从呼出的人体气体中浓缩化学物质，并且这些装置可能在基于芯片实验室的环境和健康监测系统中具有应用价值。
