School of Engineering and Computer Science, Washington State University, Vancouver, WA 98686, USA.
Human-Centric Interfaces and Engineering Program, Wallace H. Coulter Department of Biomedical Engineering, George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Biosensors (Basel). 2020 Sep 18;10(9):127. doi: 10.3390/bios10090127.
A recent development in portable biosensors allows rapid, accurate, and on-site detection of biomarkers, which helps to prevent disease spread by the control of sources. Less invasive sample collection is necessary to use portable biosensors in remote environments for accurate on-site diagnostics and testing. For non- or minimally invasive sampling, easily accessible body fluids, such as saliva, sweat, blood, or urine, have been utilized. It is also imperative to find accurate biomarkers to provide better clinical intervention and treatment at the onset of disease. At the same time, these reliable biomarkers can be utilized to monitor the progress of the disease. In this review, we summarize the most recent development of portable biosensors to detect various biomarkers accurately. In addition, we discuss ongoing issues and limitations of the existing systems and methods. Lastly, we present the key requirements of portable biosensors and discuss ideas for functional enhancements.
近年来，便携式生物传感器的发展使得对生物标志物的快速、准确和现场检测成为可能，有助于通过控制源头来防止疾病传播。为了在偏远环境中使用便携式生物传感器进行准确的现场诊断和测试，需要进行侵入性更小的样本采集。为了进行非侵入性或最小侵入性采样，已经利用了容易获得的体液，如唾液、汗液、血液或尿液。找到准确的生物标志物来提供更好的临床干预和治疗也至关重要，以便在疾病发作时进行治疗。同时，这些可靠的生物标志物也可以用于监测疾病的进展。在这篇综述中，我们总结了最近用于准确检测各种生物标志物的便携式生物传感器的发展。此外，我们还讨论了现有系统和方法存在的问题和局限性。最后，我们提出了便携式生物传感器的关键要求，并讨论了功能增强的思路。
