预测痴呆症：痴呆风险指数的作用。
Predicting dementia: role of dementia risk indices.
作者信息
Barnes Deborah E, Yaffe Kristine
机构信息
Assistant Professor of Psychiatry, University of California, San Francisco, San Francisco VA Medical Center, 4150 Clement Street, 151R, San Francisco, CA 94121, USA.
出版信息
Future Neurol. 2009 Sep 1;4(5):555-560. doi: 10.2217/fnl.09.43.
Abstract
There are currently more than 5 million people in the USA living with Alzheimer's disease and other forms of dementia, and prevalence is expected to triple over the next 40 years. As new strategies for prevention and treatment are developed, it will be critically important to be able to identify older adults who do not currently have dementia but have a high risk of developing symptoms within a few years so that they can be targeted for monitoring, prevention and early treatment. In other fields, prognostic models and risk indices are often used to identify high-risk individuals (e.g., Framingham Heart Index and Breast Cancer Risk Assessment Tool). The objective of this paper is to describe the development of Dementia Risk Indices and to discuss the potential for these tools to be incorporated into clinical and research settings for the identification of individuals with a high risk of dementia.
摘要
目前，美国有超过500万人患有阿尔茨海默病和其他形式的痴呆症，预计在未来40年患病率将增至三倍。随着预防和治疗新策略的不断发展，能够识别目前没有痴呆症但在几年内出现症状风险较高的老年人至关重要，以便对他们进行监测、预防和早期治疗。在其他领域，预后模型和风险指数经常用于识别高危个体（例如弗雷明汉心脏指数和乳腺癌风险评估工具）。本文的目的是描述痴呆症风险指数的开发，并讨论将这些工具纳入临床和研究环境以识别痴呆症高危个体的可能性。
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本文引用的文献
1
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Neurology. 2008 Sep 30;71(14):1072-9. doi: 10.1212/01.wnl.0000326894.40353.93.
2
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.胆碱酯酶抑制剂和美金刚治疗痴呆的有效性：临床实践指南的证据综述
Ann Intern Med. 2008 Mar 4;148(5):379-97. doi: 10.7326/0003-4819-148-5-200803040-00009.
3
Projecting individualized absolute invasive breast cancer risk in African American women.预测非裔美国女性个体患浸润性乳腺癌的绝对风险
J Natl Cancer Inst. 2007 Dec 5;99(23):1782-92. doi: 10.1093/jnci/djm223. Epub 2007 Nov 27.
4
Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study.痴呆临床诊断前10年日常生活工具性活动能力下降的自然史：一项基于人群的前瞻性研究。
J Am Geriatr Soc. 2008 Jan;56(1):37-44. doi: 10.1111/j.1532-5415.2007.01499.x. Epub 2007 Nov 20.
5
Diet and Alzheimer's disease.饮食与阿尔茨海默病
Curr Neurol Neurosci Rep. 2007 Sep;7(5):366-72. doi: 10.1007/s11910-007-0057-8.
6
Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies.吸烟作为痴呆和认知衰退的风险因素：前瞻性研究的荟萃分析。
Am J Epidemiol. 2007 Aug 15;166(4):367-78. doi: 10.1093/aje/kwm116. Epub 2007 Jun 14.
7
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Curr Opin Psychiatry. 2007 Jul;20(4):380-5. doi: 10.1097/YCO.0b013e32816ebc7b.
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Neurobiol Aging. 2008 Dec;29(12):1774-82. doi: 10.1016/j.neurobiolaging.2007.04.020. Epub 2007 May 30.
9
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Diabetes Care. 2007 Mar;30(3):510-5. doi: 10.2337/dc06-2089.
10
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Lancet Neurol. 2006 Sep;5(9):735-41. doi: 10.1016/S1474-4422(06)70537-3.
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