Barnes Deborah E, Yaffe Kristine
Assistant Professor of Psychiatry, University of California, San Francisco, San Francisco VA Medical Center, 4150 Clement Street, 151R, San Francisco, CA 94121, USA.
Future Neurol. 2009 Sep 1;4(5):555-560. doi: 10.2217/fnl.09.43.
There are currently more than 5 million people in the USA living with Alzheimer's disease and other forms of dementia, and prevalence is expected to triple over the next 40 years. As new strategies for prevention and treatment are developed, it will be critically important to be able to identify older adults who do not currently have dementia but have a high risk of developing symptoms within a few years so that they can be targeted for monitoring, prevention and early treatment. In other fields, prognostic models and risk indices are often used to identify high-risk individuals (e.g., Framingham Heart Index and Breast Cancer Risk Assessment Tool). The objective of this paper is to describe the development of Dementia Risk Indices and to discuss the potential for these tools to be incorporated into clinical and research settings for the identification of individuals with a high risk of dementia.
目前，美国有超过500万人患有阿尔茨海默病和其他形式的痴呆症，预计在未来40年患病率将增至三倍。随着预防和治疗新策略的不断发展，能够识别目前没有痴呆症但在几年内出现症状风险较高的老年人至关重要，以便对他们进行监测、预防和早期治疗。在其他领域，预后模型和风险指数经常用于识别高危个体（例如弗雷明汉心脏指数和乳腺癌风险评估工具）。本文的目的是描述痴呆症风险指数的开发，并讨论将这些工具纳入临床和研究环境以识别痴呆症高危个体的可能性。
