新诊断2型糖尿病患者认知障碍的患病率：慢性炎症性疾病是否导致认知衰退？
Prevalence of Cognitive Impairment in Recently Diagnosed Type 2 Diabetes Patients: Are Chronic Inflammatory Diseases Responsible for Cognitive Decline?
作者信息
Lavielle Pilar, Talavera Juan O, Reynoso Nancy, González Marissa, Gómez-Díaz Rita A, Cruz Miguel, Vázquez Felipe, Wacher Niels H
机构信息
Unidad de Investigación en Epidemiología Clínica UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México.
Unidad de Investigación en Bioquímica, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México.
出版信息
PLoS One. 2015 Oct 30;10(10):e0141325. doi: 10.1371/journal.pone.0141325. eCollection 2015.
OBJECTIVE
To estimate the prevalence of cognitive impairment (CI) among patients recently diagnosed with type 2 diabetes (RDD) and to identify any relationships between CI and RDD comorbidities.
METHODS
One thousand seven hundred twelve patients with RDD participated in a cross-sectional study. The patients' sociodemographic and clinical data were registered.
RESULTS
The sample population had an average age of 51 ± 11 years, and 63.26% of the patients were female. CI was diagnosed in 38 patients (2.2%) and was more common among both females (2.8% vs. 1.3%, p = 0.063) and the elderly (0% at an age ≤ 30 years vs. 10.4% at an age > 70 years, p = 0.0001). Rheumatoid arthritis (present in 15.8% vs. absent in 2.1%) and asthma (13% vs. 2.1%) correlated significantly with CI based on the results of our logistic regression analysis.
CONCLUSION
Age, female gender, rheumatoid arthritis and asthma are risk factors for CI in the setting of RDD.
目的
评估近期诊断为2型糖尿病（RDD）患者的认知障碍（CI）患病率，并确定CI与RDD合并症之间的关系。
方法
1712例RDD患者参与了一项横断面研究。记录患者的社会人口统计学和临床数据。
结果
样本人群的平均年龄为51±11岁，63.26%的患者为女性。38例患者（2.2%）被诊断为CI，在女性（2.8%对1.3%，p = 0.063）和老年人（年龄≤30岁时为0%，年龄>70岁时为10.4%，p = 0.0001）中更为常见。根据逻辑回归分析结果，类风湿性关节炎（存在率为15.8%，不存在率为2.1%）和哮喘（13%对2.1%）与CI显著相关。
结论
年龄、女性性别、类风湿性关节炎和哮喘是RDD患者发生CI的危险因素。
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