Beutler John A
Molecular Targets Development Program Center for Cancer Research National Cancer Institute Frederick, MD 21702 USA
Curr Protoc Pharmacol. 2009 Sep 1;46:9.11.1-9.11.21. doi: 10.1002/0471141755.ph0911s46.
Natural products have contributed to the development of many drugs for diverse indications. While most U.S. pharmaceutical companies have reduced or eliminated their in-house natural product groups, new paradigms and new enterprises have evolved to carry on a role for natural products in the pharmaceutical industry. Many of the reasons for the decline in popularity of natural products are being addressed by the development of new techniques for screening and production. This overview aims to inform pharmacologists of current strategies and techniques that make natural products a viable strategic choice for inclusion in drug discovery programs.
天然产物推动了许多用于各种适应症的药物的研发。尽管大多数美国制药公司已经缩减或裁撤了其内部的天然产物团队，但新的模式和新企业已经涌现，以在制药行业中继续发挥天然产物的作用。天然产物受欢迎程度下降的许多原因正通过筛选和生产新技术的开发得到解决。本综述旨在让药理学家了解当前的策略和技术，这些策略和技术使天然产物成为药物发现计划中可行的战略选择。
