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天然产物作为药物发现的基础。

Natural Products as a Foundation for Drug Discovery.

作者信息

Beutler John A

机构信息

Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.

出版信息

Curr Protoc Pharmacol. 2019 Sep;86(1):e67. doi: 10.1002/cpph.67.

DOI:10.1002/cpph.67
PMID:31539923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7442317/
Abstract

Many natural products have been used as drugs for the treatment of diverse indications. Although most U.S. pharmaceutical companies have reduced or eliminated their in-house natural-product research over the years, new approaches for compound screening and chemical synthesis are resurrecting interest in exploring the therapeutic value of natural products. The aim of this commentary is to review emerging strategies and techniques that have made natural products a viable strategic choice for inclusion in drug discovery programs. Published 2019. U.S. Government.

摘要

许多天然产物已被用作治疗各种适应症的药物。尽管多年来大多数美国制药公司已经减少或取消了其内部的天然产物研究，但化合物筛选和化学合成的新方法正在重新激发人们对探索天然产物治疗价值的兴趣。本评论的目的是回顾一些新兴的策略和技术，这些策略和技术使天然产物成为药物发现计划中可行的战略选择。2019年发表。美国政府。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/3f6a11d87b21/nihms-1608203-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/bc76d390067e/nihms-1608203-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/3f6a11d87b21/nihms-1608203-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/bc76d390067e/nihms-1608203-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/7169855b991d/nihms-1608203-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/b1768226a753/nihms-1608203-f0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed9/7442317/3f6a11d87b21/nihms-1608203-f0005.jpg

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