登革病毒的毒力和致病性标志物。
Dengue virus markers of virulence and pathogenicity.
作者信息
Rico-Hesse Rebeca
机构信息
Department of Virology & Immunology, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78245, USA.
出版信息
Future Virol. 2009 Nov 1;4(6):581. doi: 10.2217/fvl.09.51.
The increased spread of dengue fever and its more severe form, dengue hemorrhagic fever, have made the study of the mosquito-borne dengue viruses that cause these diseases a public health priority. Little is known about how or why the four different (serotypes 1-4) dengue viruses cause pathology in humans only, and there have been no animal models of disease to date. Therefore, there are no vaccines or antivirals to prevent or treat infection and mortality rates of dengue hemorrhagic fever patients can reach up to 20%. Cases occur mainly in tropical zones within developing countries worldwide, and control measures have been limited to the elimination of the mosquito vectors. Thus, it is imperative that we develop new methods of studying dengue virus pathogenicity. This article presents new approaches that may help us to understand dengue virus virulence and the specific mechanisms that lead to dengue fever and severe disease.
登革热及其更严重形式登革出血热的传播增加，使得对导致这些疾病的蚊媒登革病毒的研究成为公共卫生的优先事项。对于四种不同（血清型1 - 4）的登革病毒如何以及为何仅在人类中引起病理变化，人们知之甚少，并且迄今为止尚无疾病的动物模型。因此，没有预防或治疗感染的疫苗或抗病毒药物，登革出血热患者的死亡率可达20%。病例主要发生在全球发展中国家的热带地区，控制措施仅限于消灭蚊媒。因此，我们必须开发研究登革病毒致病性的新方法。本文介绍了可能有助于我们理解登革病毒毒力以及导致登革热和严重疾病的具体机制的新方法。
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