叶底珠甲醇根皮提取物对啮齿动物的行为影响。
Behavioural effects of the methanolic root bark extract of Securinega virosa in rodents.
作者信息
Magaji M G, Anuka J A, Abdu-Aguye I, Yaro A H, Hussaini I M
机构信息
Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University, Zaria, Nigeria.
出版信息
Afr J Tradit Complement Altern Med. 2008 Jan 22;5(2):147-53. doi: 10.4314/ajtcam.v5i2.31266.
Securinega virosa is used traditionally as sedative in children and in mental illnesses. In this study, the behavioral effects of methanolic root bark extract of S. virosa were investigated in mice. The results revealed that the extract significantly (P<0.05) and dose-dependently reduced the onset and prolonged the duration of sleep. The extract significantly (P<0.05) decreased exploratory activity and reduced the rate of apomorphine-induced stereotyped climbing at the doses tested (6.25-25 mg/kg). It also produced a significant and dose-dependent motor coordination deficit in mice at the doses tested (P<0.01). The intraperitoneal median lethal dose in mice was 774.6 mg/kg while the preliminary phytochemical screening revealed the presence of alkaloids, tannins, saponins and flavonoids. These results suggest that methanolic root bark extract of S. virosa contains biologically active principles that are sedative in nature and lend pharmacological credence to the ethnomedical use of the plant.
叶底珠传统上被用作儿童和精神疾病的镇静剂。在本研究中，对叶底珠甲醇根皮提取物在小鼠中的行为效应进行了研究。结果显示，该提取物显著（P<0.05）且剂量依赖性地缩短了入睡时间并延长了睡眠时间。在测试剂量（6.25 - 25毫克/千克）下，该提取物显著（P<0.05）降低了探索活动，并降低了阿扑吗啡诱导的刻板攀爬速率。在测试剂量下，它还在小鼠中产生了显著且剂量依赖性的运动协调缺陷（P<0.01）。小鼠腹腔注射的半数致死剂量为774.6毫克/千克，而初步植物化学筛选显示存在生物碱、单宁、皂苷和黄酮类化合物。这些结果表明，叶底珠甲醇根皮提取物含有具有镇静性质的生物活性成分，为该植物的民族医学用途提供了药理学依据。
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