Mahmood Samira Abdulla, Lindequist Ulrike
Department of Pharmacology, Faculty of Medicine and Health Sciences, Aden University, Aden, Yemen.
Afr J Tradit Complement Altern Med. 2008 Apr 10;5(3):271-7. doi: 10.4314/ajtcam.v5i3.31283.
This study investigated the effect of Catha edulis (khat) on some important parameters of the metabolic syndrome in Wistar Ottawa Karlsburg W (WOKW) rat. The animals were fed with the standard chow containing 5% air dried pulverized khat leaves for 14 days; followed by the standard chow for 16 days. The khat leaves were sorted into green (khat light; KL) and crimson (khat dark; KD) leaves. The control rats were fed on standard chow. Blood glucose (G), serum insulin, serum leptin and serum lipids (triglycerides, total cholesterol, HDL-, LDL-, and VLDL cholesterol) were determined. Feeding with khat leaves reduced the body weight and the triglyceride level of the animals. The effect of KD on these parameters was stronger than that of KL. KD lowered the blood glucose concentration and the leptin content whereas KL was inactive. The khat intake had no significant influence on serum insulin, total serum cholesterol, HDL-, LDL- and VLDL-cholesterol.
本研究调查了恰特草对渥太华卡尔兹堡W（WOKW）系雄性大鼠代谢综合征一些重要参数的影响。给动物喂食含5%风干粉碎恰特草叶的标准饲料14天；随后喂食标准饲料16天。将恰特草叶分为绿色（淡恰特草；KL）和深红色（深恰特草；KD）叶。对照大鼠喂食标准饲料。测定血糖（G）、血清胰岛素、血清瘦素和血清脂质（甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白胆固醇）。喂食恰特草叶降低了动物的体重和甘油三酯水平。KD对这些参数的影响强于KL。KD降低了血糖浓度和瘦素含量，而KL无此作用。摄入恰特草对血清胰岛素、总血清胆固醇、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白胆固醇无显著影响。
