利用 ESI FTICR-MS 分析海洋海绵 Luffariella variabilis 的幼虫。

Australian Institute of Marine Science, Townsville, Queensland, 4810, Australia.

Mar Drugs. 2010 Jan 22;8(1):190-9. doi: 10.3390/md8010190.

The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.

胎生大堡礁海绵 Luffariella variabilis（Poléjaeff 1884）含有一系列次生代谢产物，包括 manoalide（1）和 manoalide 单乙酸酯（3）。ESI（+）FTICR-MS 精确质量测定首次用于检测单个 L. variabilis 幼虫的有机提取物中仅存在 3 的情况，表明母体产生的 3 被隔离在幼虫中。由于 3 先前已显示具有抗菌和群体感应抑制活性，并且容易转化为 1，其也表现出类似的活性，因此它可能为抵御捕食和微生物攻击提供了化学防御。