Bose Sekhar K, Dewanjee Saikat, Sen Gupta Avijit, Samanta Kartick C, Kundu Mintu, Mandal Subhash C
Division of Biotechnology and Microbiology, Himalayan Pharmacy Institute, Majhitar, East Sikkim 737136, Sikkim, India.
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):97-102.
Rhus semialata Murr. (Anacardiaceae) is a deciduous tree of north eastern India. The fruit of this plant is traditionally used to control diarrhoea and dysentery. The Present study was undertaken to evaluate anti-diarrhoeal potency of methanol extract of fruits of R. semialata using Wister albino rats to substantiate folklore claims. The extract at graded doses (100, 200, 400 and 600 mg/kg body weight) was investigated for anti-diarrhoeal activity in term of reduction in the rate of defecation in castor oil induced diarrhoea. To understand the mechanism of its antidiarrhoeal activity, the gastrointestinal transit and PGE(2)-induced intestinal fluid accumulation (enteropooling) were further evaluated. At graded doses, the extract showed a remarkable anti-diarrhoeal activity evidenced by the reduction in the rate of defecation up to 80.70% of control diarrhoeal animals at the dose of 600 mg/kg body weight. Results are comparable to that of standard drug diphenoxylate (50 mg/kg body weight). Extract produced profound decrease in intestinal transit (8.02-47.05%) at selected doses comparable to that of single intraperitoneal injection of standard drug atropine sulphate at doses of 0.1 mg/kg body weight. It significantly inhibited PGE(2)-induced enteropooling (21.98-56.03%). The results indicated that the methanol extract of the fruits of R. semialata possesses significant anti-diarrhoeal effect and substantiated the use of this herbal remedy as a non-specific treatment for diarrhoea in folk medicine.
盐肤木（漆树科）是印度东北部的一种落叶乔木。这种植物的果实传统上用于控制腹泻和痢疾。本研究旨在使用Wistar白化大鼠评估盐肤木果实甲醇提取物的抗腹泻效力，以证实民间说法。以分级剂量（100、200、400和600毫克/千克体重）的提取物，针对蓖麻油诱导腹泻中排便率的降低来研究其抗腹泻活性。为了解其抗腹泻活性的机制，进一步评估了胃肠道转运和前列腺素E2诱导的肠液积聚（肠内积液）。在分级剂量下，提取物显示出显著的抗腹泻活性，在600毫克/千克体重剂量下，排便率降低至对照腹泻动物的80.70%，证明了这一点。结果与标准药物地芬诺酯（50毫克/千克体重）相当。提取物在选定剂量下使肠道转运显著降低（8.02 - 47.05%），与单次腹腔注射0.1毫克/千克体重剂量的标准药物硫酸阿托品相当。它显著抑制前列腺素E2诱导的肠内积液（21.98 - 56.03%）。结果表明，盐肤木果实的甲醇提取物具有显著的抗腹泻作用，并证实了这种草药疗法在民间医学中作为腹泻非特异性治疗方法的应用。
