Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam.
Arch Pharm Res. 2009 Dec;32(12):1695-8. doi: 10.1007/s12272-009-2205-y. Epub 2010 Feb 17.
One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM.
从越南海洋海绵 Ianthella sp. 中分离得到一个新的 C(29) 甾醇，具有 C-25 和 C-26 位的环丙烷环，aragusteroketal B(1)和 aragusterol B(2)。通过广泛的光谱分析阐明了它们的结构。1 和 2 对 MCF-7、SK-Hep-1 和 HeLa 细胞系均显示出中等的细胞毒性活性，IC(50)范围为 12.8-27.8 μM。
