从越南海洋海绵lanthella sp. 中分离得到的一种具有 C-25 和 C-26 位环丙烷环的新型 C29-甾醇。

A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.

机构信息

Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam.

出版信息

Arch Pharm Res. 2009 Dec;32(12):1695-8. doi: 10.1007/s12272-009-2205-y. Epub 2010 Feb 17.

DOI:10.1007/s12272-009-2205-y

PMID:20162396

Abstract

One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM.

摘要

从越南海洋海绵 Ianthella sp. 中分离得到一个新的 C(29) 甾醇，具有 C-25 和 C-26 位的环丙烷环，aragusteroketal B(1)和 aragusterol B(2)。通过广泛的光谱分析阐明了它们的结构。1 和 2 对 MCF-7、SK-Hep-1 和 HeLa 细胞系均显示出中等的细胞毒性活性，IC(50)范围为 12.8-27.8 μM。