一种源自越南海洋海绵龟甲团扇海绵的新型甾醇及其生物活性。

A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities.

作者信息

Nguyen Hien Minh, Ito Takuya, Win Nwet Nwet, Vo Hung Quoc, Nguyen Hoai Thi, Morita Hiroyuki

机构信息

a Institute of Natural Medicine , University of Toyama , Toyama , Japan.

b Department of Chemistry , University of Yangon , Yangon , Myanmar.

出版信息

Nat Prod Res. 2019 Apr;33(8):1175-1181. doi: 10.1080/14786419.2018.1465057. Epub 2018 Apr 23.

DOI:10.1080/14786419.2018.1465057

PMID:29683344

Abstract

A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC values ranging from 29.0 to 68.0 μM.

摘要

从越南采集的海洋海绵龟甲海绵（Xestospongia testudinaria）中分离出一种新的甾醇——朗氏甾醇A（1），以及两种已知的甾醇2和3。通过广泛的光谱分析并与已发表的数据进行比较，阐明了它们的化学结构。新化合物1和已知化合物3对三种人类癌细胞系（A549，肺癌；MCF7，乳腺癌；HeLa，宫颈癌）和一种人类正常细胞系（WI-38成纤维细胞）表现出中等的细胞毒性活性，IC值范围为29.0至68.0μM。