葡萄糖转运蛋白9（SLC2A9）基因变异与饮食习惯在血清尿酸调节中的相互作用。
Interactions between genetic variants in glucose transporter type 9 (SLC2A9) and dietary habits in serum uric acid regulation.
作者信息
Jeroncić Iris, Mulić Rosanda, Klismanić Zorana, Rudan Diana, Boban Mladen, Zgaga Lina
机构信息
Medical School, University of Split, Split, Croatia.
出版信息
Croat Med J. 2010 Feb;51(1):40-7. doi: 10.3325/cmj.2010.51.40.
AIM
To investigate possible interactions between genetic variants in glucose transporter type 9 (SLC2A9) gene and dietary habits in serum uric acid regulation.
METHODS
Participants for this study were recruited from two isolated Croatian island communities of Vis (n=918) and Korcula (n=898). Three single nucleotide polymorphisms (SNP) from the SLC2A9 gene (rs1014290, rs6449213, rs737267) were correlated with dietary habits and uric acid.
RESULTS
A significant decrease in uric acid levels was recorded with increasing consumption of milk, sour cream, duck and turkey, and eggs. The only significant interaction was found between potato consumption and rs737267 and a near-significant interaction was found between soft drinks and rs1014290 (interaction P=0.068). Increased consumption of soft drinks interacting with the TT genotype at rs1014290 increased serum uric acid. No significant interactions were observed between food products consumption and rs6449213.
CONCLUSION
There is a certain extent of interaction between SLC2A9 and dietary patterns in serum uric acid determination. The metabolic effect of soft drinks seems to be determined by the underlying genotype of rs1014290.
目的
研究葡萄糖转运蛋白9（SLC2A9）基因中的遗传变异与饮食习惯在血清尿酸调节中的可能相互作用。
方法
本研究的参与者招募自克罗地亚两个孤立的岛屿社区，维斯岛（n = 918）和科尔丘拉岛（n = 898）。SLC2A9基因的三个单核苷酸多态性（SNP）（rs1014290、rs6449213、rs737267）与饮食习惯和尿酸相关。
结果
随着牛奶、酸奶油、鸭肉、火鸡肉和鸡蛋摄入量的增加，尿酸水平显著降低。仅发现土豆摄入量与rs737267之间存在显著相互作用，软饮料与rs1014290之间存在接近显著的相互作用（相互作用P = 0.068）。软饮料摄入量增加与rs1014290处的TT基因型相互作用会增加血清尿酸。未观察到食品摄入量与rs6449213之间存在显著相互作用。
结论
SLC2A9与血清尿酸测定中的饮食模式之间存在一定程度的相互作用。软饮料的代谢效应似乎由rs1014290的潜在基因型决定。
Zotero 插件