Centro de Investigación en Políticas, Población y Salud de la Facultad de Medicina de la Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México 14610, Mexico.
Nutrients. 2019 Jun 14;11(6):1336. doi: 10.3390/nu11061336.
Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot Genome-wide association study GWAS was performed in a subgroup of participants ( = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) associated with serum uric acid levels were validated in all the HWCS participants ( = 1939) and replicated in independent children ( = 1080) and adult ( = 1073) case-control studies. The meta-analysis of the whole HWCS and replication samples identified three SNPs: ( = 2.3 × 10), ( = 8.2 × 10) and ( = 1.1 × 10); and an missense SNP, ( = 1.0 × 10). Among the non-genetic factors identified, the visceral adiposity index, smoking, the metabolic syndrome and its components (waist circumference, blood pressure, glucose and hyperlipidemia) were associated with increased serum uric acid levels and hyperuricemia ( < 0.05). Among the female HWCS participants, the odds ratio for hyperuricemia was 1.24 (95% CI, 1.01-1.53) per unit increase in soft drink consumption. As reported in other studies, our findings indicate that diet, adiposity and genetic variation contribute to the elevated prevalence of hyperuricemia in Mexico.
高尿酸血症的风险受遗传和环境因素的影响。我们的目的是确定与墨西哥人血清尿酸水平和高尿酸血症相关的因素。在卫生工作者队列研究（HWCS）的参与者亚组（= 411）中进行了全基因组关联研究（GWAS）。在所有 HWCS 参与者（= 1939）中验证了与血清尿酸水平相关的单核苷酸多态性（SNP），并在独立的儿童（= 1080）和成人（= 1073）病例对照研究中进行了复制。整个 HWCS 和复制样本的荟萃分析确定了三个 SNP：（= 2.3×10），（= 8.2×10）和（= 1.1×10）；和一个错义 SNP，（= 1.0×10）。在确定的非遗传因素中，内脏脂肪指数、吸烟、代谢综合征及其成分（腰围、血压、血糖和血脂异常）与血清尿酸水平升高和高尿酸血症相关（<0.05）。在女性 HWCS 参与者中，软饮料摄入量每增加一个单位，高尿酸血症的比值比为 1.24（95%CI，1.01-1.53）。与其他研究报告的结果一致，我们的研究结果表明，饮食、肥胖和遗传变异导致了墨西哥高尿酸血症的高发。
