创伤后应激障碍诊断和应急管理程序对接受 LAAM 维持治疗的同时依赖可卡因和阿片类药物的个体可卡因使用的影响：一项回顾性分析。
Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis.
机构信息
Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
出版信息
Am J Addict. 2010 Mar-Apr;19(2):169-77. doi: 10.1111/j.1521-0391.2009.00025.x.
Abstract
This randomized clinical trial retrospectively examined the effect of post-traumatic stress disorder (PTSD) and contingency management (CM) on cocaine use in opioid and cocaine dependent individuals maintained on high or low-dose LAAM randomly assigned to CM or a yoked-control condition. Cocaine-positive urines decreased more rapidly over time in those without PTSD versus those with PTSD in the noncontingency condition. In participants with PTSD, CM resulted in fewer cocaine-positive urines compared to the noncontingent condition. This suggests that CM may help improve the potentially worse outcomes in opioid- and cocaine-dependent individuals with PTSD compared to those without PTSD. (Am J Addict 2010;00:1-9).
摘要
这项随机临床试验回顾性地研究了创伤后应激障碍（PTSD）和应急管理（CM）对接受高或低剂量 LAAM 维持治疗的阿片类药物和可卡因依赖个体的可卡因使用的影响，这些个体随机分配到 CM 或配对对照条件。在非应急条件下，无 PTSD 的个体与有 PTSD 的个体相比，可卡因阳性尿液随时间的推移减少得更快。在有 PTSD 的参与者中，CM 与非应急条件相比，可卡因阳性尿液减少。这表明，与无 PTSD 的个体相比，CM 可能有助于改善 PTSD 合并阿片类药物和可卡因依赖个体的潜在更差结局。（美国成瘾杂志 2010 年；00:1-9）。
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