Li Yunfeng, Gao Ying, Song Guodong, Liu Xianwen, Hu Jing
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, China.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):700-5. doi: 10.1016/j.tripleo.2009.10.041. Epub 2010 Feb 16.
This study investigated the effect of locally immobilized bisphosphonates and systemic estrogen replacement therapy on fixation of hydroxyapatite-coated screws in ovariectomized rats.
Twelve weeks after being ovariectomized, each of the 20 rats received 2 hydroxyapatite-coated screws in the proximal tibia, with or without immobilized bisphosphonates. Half of the animals also received subcutaneous injections of 17beta-estradiol. Thus, there were 4 groups: control, estrogen, bisphosphonates, and estrogen plus bisphosphonates. Tibiae with screws were measured by microscopic computerized tomography and push-out test 12 weeks after implantation.
Combined treatment had the strongest effects, with the bone volume ratio around screws and the percentage of osteointegration significantly increased by 2.3-fold and 1.9-fold and the push-out force by 3.3-fold compared with untreated control samples. Monotherapy also enhanced the fixation of screws, although less.
Systemic estrogen replacement therapy and locally immobilized bisphosphonates had additive effects on fixation of hydroxyapatite-coated screws in ovariectomized rats.
本研究调查了局部固定双膦酸盐和全身雌激素替代疗法对去卵巢大鼠羟基磷灰石涂层螺钉固定的影响。
20只大鼠去卵巢12周后，每只大鼠在胫骨近端植入2枚羟基磷灰石涂层螺钉，螺钉植入时伴或不伴固定双膦酸盐。半数动物还接受皮下注射17β-雌二醇。因此，共有4组：对照组、雌激素组、双膦酸盐组和雌激素加双膦酸盐组。植入12周后，通过显微计算机断层扫描和推出试验对植入螺钉的胫骨进行检测。
联合治疗效果最强，与未治疗的对照样本相比，螺钉周围骨体积比和骨整合百分比显著增加，分别增加了2.3倍和1.9倍，推出力增加了3.3倍。单一疗法也增强了螺钉的固定，尽管效果较弱。
全身雌激素替代疗法和局部固定双膦酸盐对去卵巢大鼠羟基磷灰石涂层螺钉的固定具有相加作用。
