Ribes Juan Manuel, Montava Rebeca, Téllez-Castillo Carlos J, Fernández-Jiménez Manuel, Buesa Javier
Department of Microbiology, School of Medicine, University of Valencia, and Hospital Clínico Universitario, 46010 Valencia, Spain.
Clin Vaccine Immunol. 2010 Apr;17(4):545-9. doi: 10.1128/CVI.00382-09. Epub 2010 Feb 17.
Viruses are among the most common causes of acute gastroenteritis. In recent years, new viruses causing outbreaks of acute gastroenteritis have been described. Among these, Aichi virus was identified in Japan in 1989. Aichi virus belongs to the Kobuvirus genus in the family Picornaviridae. This virus has been detected in outbreaks of gastroenteritis associated with oyster consumption and in pediatric stool samples, but little is known about its epidemiology or pathogenesis. In the present study, the prevalence of antibodies to Aichi virus in a Spanish population was determined between 2007 and 2008 by using an enzyme-linked immunosorbent assay (ELISA). As in previous studies, a high seroprevalence of antibodies to Aichi virus (70%) was observed, with levels differing according to age. We observed significant differences in titers of antibody to Aichi virus among different age groups, grouped by decades. We report high ELISA and neutralizing antibody titers, and both titers fitted a sigmoid curve significantly. However, this virus is seldom detected; therefore, further studies are needed to gain a better understanding of its importance as a pathogenic agent.
病毒是急性胃肠炎最常见的病因之一。近年来，已发现一些可引发急性胃肠炎疫情的新型病毒。其中，1989年在日本发现了爱知病毒。爱知病毒属于小RNA病毒科心病毒属。这种病毒已在与食用牡蛎相关的胃肠炎疫情以及儿童粪便样本中被检测到，但对其流行病学或发病机制了解甚少。在本研究中，2007年至2008年期间，采用酶联免疫吸附测定（ELISA）法测定了西班牙人群中抗爱知病毒抗体的流行情况。与之前的研究一样，观察到抗爱知病毒抗体的血清阳性率较高（70%），且抗体水平因年龄而异。我们观察到按十年分组的不同年龄组之间，抗爱知病毒抗体滴度存在显著差异。我们报告了较高的ELISA和中和抗体滴度，且两种滴度均显著拟合S形曲线。然而，这种病毒很少被检测到；因此，需要进一步研究以更好地了解其作为病原体的重要性。
