Laboratório Nacional de Investigação Veterinária, Instituto Nacional de Recursos Biológicos, I. P., Portugal.
J Gen Virol. 2010 Jun;91(Pt 6):1646-50. doi: 10.1099/vir.0.018879-0. Epub 2010 Feb 17.
Active transmissible spongiform encephalopathy (TSE) surveillance in small ruminants across Europe was implemented in 2002 following the epizootic of bovine spongiform encephalopathy. Here, we report the potential emergence of classical scrapie in Portugal, in a background of enzootic atypical scrapie. Between 2003 and 2008, 375,459 small ruminants were screened in total, with 328 animals confirmed positive for NOR98 atypical scrapie. During this period, the prevalence rate of atypical scrapie for all years combined was 0.0874% across the country. In this scenario, classical scrapie emerged as a single outbreak in 2008, with 12 identified cases. In contrast to other European countries, where classical scrapie has been enzootic for decades, these data indicate that, in Portugal, atypical scrapie is the predominant form of TSE. The findings reported here will have implications for the control of classical scrapie in Portugal, namely in terms of keeping the country free of enzootic classical scrapie.
2002 年，在牛海绵状脑病（BSE）爆发后，欧洲开始对小反刍动物进行主动可传播海绵状脑病（TSE）监测。在此，我们报告了葡萄牙经典羊瘙痒病的潜在出现，背景是地方性非典型羊瘙痒病。2003 年至 2008 年间，共对 375459 只小反刍动物进行了筛查，其中 328 只动物被确诊为 NOR98 非典型羊瘙痒病阳性。在此期间，全国所有年份的非典型羊瘙痒病的流行率合计为 0.0874%。在此背景下，2008 年经典羊瘙痒病作为单一疫情出现，确诊 12 例。与其他经典羊瘙痒病已流行数十年的欧洲国家不同，这些数据表明，在葡萄牙，非典型羊瘙痒病是 TSE 的主要形式。本报告中的发现将对葡萄牙经典羊瘙痒病的控制产生影响，特别是在使该国免受地方性经典羊瘙痒病影响方面。
