Graduate Program in Biomedical Engineering, University of Arizona, Tucson, Arizona 85721-0093, USA.
J Neurosci. 2010 Feb 17;30(7):2650-61. doi: 10.1523/JNEUROSCI.1617-09.2010.
Spontaneous reactivation of previously stored patterns of neural activity occurs in hippocampus and neocortex during non-rapid eye movement (NREM) sleep. Notable features of the neocortical local field potential during NREM sleep are high-amplitude, low-frequency thalamocortical oscillations including K-complexes, low-voltage spindles, and high-voltage spindles. Using combined neuronal ensemble and local field potential recordings, we show that prefrontal stored-trace reactivation is correlated with the density of down-to-up state transitions of the population of simultaneously recorded cells, as well as K-complexes and low-voltage spindles in the local field potential. This result strengthens the connection between reactivation and learning, as these same NREM sleep features have been correlated with memory. Although memory trace reactivation is correlated with low-voltage spindles, it is not correlated with high-voltage spindles, indicating that despite their similar frequency characteristics, these two oscillations serve different functions.
在非快速眼动 (NREM) 睡眠期间，先前储存的神经活动模式会在海马体和新皮层中自发重新激活。NREM 睡眠期间新皮层局部场电位的显著特征是高振幅、低频丘脑皮质振荡，包括 K 复合波、低电压纺锤波和高电压纺锤波。使用组合神经元集合和局部场电位记录，我们表明前额叶存储痕迹的重新激活与同时记录的细胞群体的向下到向上状态转换的密度相关，以及局部场电位中的 K 复合波和低电压纺锤波相关。这一结果加强了重新激活和学习之间的联系，因为这些相同的 NREM 睡眠特征与记忆有关。尽管记忆痕迹的重新激活与低电压纺锤波相关，但与高电压纺锤波无关，这表明尽管它们具有相似的频率特征，但这两种振荡具有不同的功能。
