Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Aging Health. 2010 Apr;22(3):384-98. doi: 10.1177/0898264309359421. Epub 2010 Feb 17.
To determine associations between changes in obesity and vigorous physical activity (PA) status and depressive symptoms in a cohort aged 51 to 61 years at baseline.
Two waves (1992, 1998) of Health and Retirement Study data were used to divide participants into four obesity and four vigorous PA status categories based on change in or maintenance of their 1992 status in 1998. Depressive symptoms were defined as the upper quintile score (women >/= 4, men >/= 3) on the eight-item Center for Epidemiologic Studies-Depression Scale. Logistic regression determined adjusted odds ratios for depressive symptoms associated with obesity and vigorous PA status.
Among men, no significant associations were found. Among women, decreasing from high vigorous PA status and maintenance of obese status were independently associated with increased odds for depressive symptoms in 1998.
The findings illustrate the importance of examining gender differences in studies of risk factors for depression.
在基线时年龄为 51 至 61 岁的队列中，确定肥胖和剧烈身体活动（PA）状态变化与抑郁症状之间的关联。
使用健康与退休研究（Health and Retirement Study）的两个数据波次（1992 年、1998 年），根据参与者在 1998 年维持或改变其 1992 年的状态，将他们分为四个肥胖和四个剧烈 PA 状态类别。抑郁症状的定义为八个项目的流行病学研究中心抑郁量表（Center for Epidemiologic Studies-Depression Scale）的上五分位数评分（女性>/=4，男性>/=3）。逻辑回归确定了与肥胖和剧烈 PA 状态相关的抑郁症状的调整后比值比。
在男性中，没有发现显著的关联。在女性中，从高剧烈 PA 状态下降和维持肥胖状态与 1998 年抑郁症状的发生几率增加独立相关。
这些发现说明了在研究抑郁风险因素时，考虑性别差异的重要性。
