Department of Ophthalmology, Fujita Health University Banbuntane Hotokukai Hospital, Aichi, Japan.
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3210-5. doi: 10.1167/iovs.09-4637. Epub 2010 Feb 17.
To investigate the functional characteristics of the detached retina on a serous retinal detachment (SRD) in eyes with central serous chorioretinopathy (CSC) with spared visual acuity.
Multifocal electroretinograms (mfERGs) were recorded with a long recording time of 14 minutes, 34 seconds, to obtain accurate measurement of the second-order kernel (K2.1), an index of functional adaptability of the retina, from seven eyes with CSC (visual acuity, >or=1.0). The first-order kernel (K1) and the K2.1, elicited by stimulating the area of the SRD, were compared with those from the corresponding areas in eyes of 15 age-matched volunteers (controls) and in 6 eyes of patients with diabetic retinopathy (DR) that have been reported to have a K2.1 attenuation.
K2.1 was essentially flat in the SRD eye. The K2.1 amplitude and log-scaled amplitude ratio of K2.1 to K1 (K2.1/K1) were severely reduced (to <95% confidence interval [CI] of control levels) in all eyes. The value of K2.1/K1 of the SRD was less than that in any of the control and DR eyes. K1 was moderately reduced but was not smaller than the 95% CI of control eyes. The mfERGs from the area without the SRD and those from the fellow eyes did not differ significantly from those in control eyes.
A possible cause of the flat K2.1 observed on the SRD is the separation of the sensory retina. A substantial disparity between the recovery of cones and rods could contribute to the loss of retinal adaptability, resulting in the flat K2.1 as well as the unique visual impairments in CSC eyes.
研究伴有保留视力的中心性浆液性脉络膜视网膜病变（CSC）患者浆液性视网膜脱离（SRD）中脱离视网膜的功能特征。
对 7 只 CSC 眼（视力≥1.0）进行了长时间 14 分 34 秒的多焦视网膜电图（mfERG）记录，以获得视网膜功能适应性的二阶核（K2.1）的准确测量，这是一个指标。比较了刺激 SRD 区域所引起的一阶核（K1）和 K2.1，与 15 名年龄匹配的志愿者（对照组）和 6 名已报道 K2.1 衰减的糖尿病性视网膜病变（DR）患者眼中相应区域的 K1 和 K2.1。
SRD 眼中的 K2.1 基本平坦。所有眼的 K2.1 幅度和 K2.1 与 K1 的对数标度幅度比（K2.1/K1）均严重降低（低于对照组水平的 95%置信区间[CI]）。SRD 的 K2.1/K1 值小于任何对照组和 DR 眼的值。K1 中度降低，但不小于对照组眼的 95%CI。无 SRD 的区域和对侧眼的 mfERG 与对照组无显著差异。
在 SRD 上观察到的平坦 K2.1 的可能原因是感觉视网膜的分离。视锥细胞和视杆细胞的恢复之间存在显著差异，可能导致视网膜适应性丧失，从而导致平坦的 K2.1 以及 CSC 眼独特的视力障碍。
