Department of Ophthalmology, Eye and ENT Hospital of Fudan University School of Medicine, Shanghai, China.
Cornea. 2010 Apr;29(4):404-8. doi: 10.1097/ICO.0b013e3181bd476c.
To compare the dynamic changes in lower tear meniscus area (TMA) and height after instillation of artificial tears in patients with dry eye and healthy controls.
Twenty-two eyes of 11 patients with dry eye and twenty eyes of 10 age- and sex-matched healthy subjects were included. The inferior tear meniscus height and area measurements were taken before and after instillation of 35 μL carboxymethyl cellulose (CMC) 0.5% and 1.0% (Allergan, Irvine, CA) on 2 consecutive days. The measurements were obtained before and 1, 5, 10, 15, and 30 minutes after instillation using anterior segment optical coherence tomography, RTVue-100 (RTVue, Optovue, Inc).
The baseline lower TMA and height in the dry eye group were significantly lower than in the control group. A significant increase in TMA and height was found at 1 minute post instillation of 0.5% CMC in both groups, with findings returning to baseline levels at 5 and 10 minutes post instillation in the control group and dry eye group, respectively. The increase in TMA and height persisted for a longer time period in both groups with 1% CMC, versus 0.5% CMC. At 15 and 30 minutes, both tear meniscus parameters were still significantly higher in the control group and dry eye group, respectively.
Artificial tears provide a significant yet temporary improvement in the tear meniscus. The anterior segment optical coherence tomography is valuable to measure dynamic changes in the tear meniscus.
比较干眼症患者和健康对照者滴用人工泪液后下泪膜月牙高度和面积的动态变化。
纳入 11 例（22 只眼）干眼症患者和 10 例（20 只眼）年龄和性别匹配的健康对照者。在连续 2 天内，每只眼滴用 35 μL 羧甲基纤维素（CMC）0.5%和 1.0%（爱尔康，欧文，加利福尼亚）前后，分别使用眼前节光学相干断层扫描（RTVue-100，Optovue，Inc.）测量下泪膜月牙高度和面积。在滴用后即刻、1、5、10、15 和 30 分钟进行测量。
干眼症组的下泪膜月牙基线高度和面积明显低于对照组。两组患者在滴用 0.5% CMC 后 1 分钟时 TMA 和高度均显著增加，对照组在 5 分钟和干眼症组在 10 分钟时恢复至基线水平。与 0.5% CMC 相比，1% CMC 在两组中的 TMA 和高度增加持续时间更长。在 15 和 30 分钟时，对照组和干眼症组的 TMA 和高度参数仍显著高于基线。
人工泪液可显著改善泪膜月牙，但仅为暂时改善。眼前节光学相干断层扫描可用于测量泪膜月牙的动态变化。
