不同玻璃酸钠滴眼液滴眼后泪膜半月板的光学相干断层扫描评估。

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation.

机构信息

Department of Optics II (Optometry and Vision), Faculty of Optic and Optometry, Complutense University of Madrid, Madrid, Spain.

Ocupharm Group Research, Department of Biochemistry and Molecular Biology IV, Faculty of Optics and Optometry, University Complutense of Madrid, Madrid, Spain.

出版信息

Acta Ophthalmol. 2019 Mar;97(2):e162-e169. doi: 10.1111/aos.13887. Epub 2018 Oct 2.

DOI:10.1111/aos.13887

PMID:30280515

Abstract

PURPOSE

To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions.

METHODS

An experimental, double-masked, randomized study was performed. Twenty-three healthy subjects (16 women and seven men; mean age 23.57 ± 2.56 years) participated in this study. About 35 μl of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus measurements (height, depth and turbidity) were taken with OCT at 30 seconds and 1, 3, 5, 10 and 20 min after instillation. Subsequently, the Schirmer test and tear break-up time (TBUT) were evaluated.

RESULTS

Tear meniscus depth and tear meniscus height showed a significant increase with all solutions compared to basal values: up to 3 min for 0.1% SH, up to 5 min for 0.2% and up to 10 min for 0.3% SH ophthalmic solution. Tear meniscus turbidity was also increased at 30 seconds for 0.1%, 0.2% and 0.3% SH artificial tears (p < 0.05). This increase remained significant for up to 1 min for 0.2% and 0.3% SH solutions (p < 0.05). After 5 min of saline and 0.1% SH instillation, the turbidity was lower than basal values (p < 0.05). There was a significant increase in the TBUT for all solutions after instillation (p < 0.05). No differences between the Schirmer pre- and postinstillation were found (p > 0.05). Finally, the comfort was significantly improved for all ophthalmic solutions (p < 0.05).

CONCLUSION

Sodium hyaluronate (SH) ophthalmic solutions increase residence time in healthy subjects and are positively correlated with its concentration and therefore the viscosity.

摘要

目的

使用光学相干断层扫描（OCT）评估不同浓度的玻璃酸钠（SH）眼用溶液滴注后泪膜半月板动力学的变化。

方法

进行了一项实验性、双盲、随机研究。共有 23 名健康受试者（16 名女性和 7 名男性；平均年龄 23.57±2.56 岁）参与了这项研究。在随机指定的眼睛中滴注约 35μl 的 0.1%、0.2%、0.3%SH 眼用溶液和生理盐水。在滴注后 30 秒以及 1、3、5、10 和 20 分钟时，使用 OCT 测量泪膜半月板（高度、深度和混浊度）。随后，评估了 Schirmer 测试和泪膜破裂时间（TBUT）。

结果

与基础值相比，所有溶液均可使泪膜半月板深度和高度显著增加：0.1%SH 增加至 3 分钟，0.2%SH 增加至 5 分钟，0.3%SH 增加至 10 分钟。在 30 秒时，0.1%、0.2%和 0.3%SH 人工泪液的泪膜半月板混浊度也增加（p<0.05）。对于 0.2%和 0.3%SH 溶液，这种增加持续至 1 分钟时仍具有统计学意义（p<0.05）。在滴注生理盐水和 0.1%SH 5 分钟后，混浊度低于基础值（p<0.05）。滴注后所有溶液的 TBUT 均显著增加（p<0.05）。在滴注前后，Schirmer 测试均无差异（p>0.05）。最后，所有眼用溶液的舒适度均显著改善（p<0.05）。