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核心技术专利：CN118964589B侵权必究
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具有超顺磁性氧化铁 - 二氧化硅核的双功能金纳米壳，适用于磁共振成像和光热疗法。

Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide-Silica Core Suitable for Both MR Imaging and Photothermal Therapy.

作者信息

Ji Xiaojun, Shao Ruping, Elliott Andrew M, Stafford R Jason, Esparza-Coss Emilio, Bankson James A, Liang Gan, Luo Zhi-Ping, Park Keeseong, Markert John T, Li Chun

机构信息

Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.

Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.

出版信息

J Phys Chem C Nanomater Interfaces. 2007 Apr 6;111(17):6245-6251. doi: 10.1021/jp0702245.

DOI:10.1021/jp0702245
PMID:20165552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2822349/
Abstract

We describe the synthesis, characterization, and use of hybrid nanoparticles with a superparamagnetic iron oxide (SPIO) core and a gold nanoshell. These multifunctional nanoparticles, designated SPIO-Au nanoshells, displayed superparamagnetic characteristics and a significant absorbance in the near-infrared (NIR) region of the electromagnetic spectrum. In addition, they exhibited high transverse relaxivity, , and a large ratio and therefore could be imaged by MRI to obtain T-weighted images. Moreover, SPIO-Au nanoshells showed efficient photo-thermal effect when exposed to NIR light. The use of SPIO-Au nanoshells, with their combination of unique magnetic and optical properties, should enhance the efficacy of nanoshell-mediated photo-thermal therapy by making it possible to direct more nanoparticles to tumors through the application of external magnetic field and by permitting real-time MRI imaging of the distribution of the nanoparticles before, during, and after photo-thermal therapy.

摘要

我们描述了具有超顺磁性氧化铁（SPIO）核心和金纳米壳的混合纳米颗粒的合成、表征及应用。这些多功能纳米颗粒，命名为SPIO-金纳米壳，表现出超顺磁性特性以及在电磁光谱近红外（NIR）区域有显著吸光度。此外，它们具有高横向弛豫率， ，以及大的 比，因此可通过磁共振成像（MRI）获得T加权图像。而且，SPIO-金纳米壳在近红外光照射下显示出高效的光热效应。SPIO-金纳米壳独特的磁性和光学特性相结合，通过施加外部磁场可将更多纳米颗粒导向肿瘤，并能在光热治疗前、治疗期间和治疗后对纳米颗粒分布进行实时MRI成像，有望提高纳米壳介导的光热治疗效果。

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[7]
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[8]
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[10]
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本文引用的文献

[1]
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