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The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field.外部磁场可增强超顺磁性氧化铁纳米颗粒（SPION）在人工三层膜上的渗透性。
J Nanobiotechnology. 2006 Apr 7;4:4. doi: 10.1186/1477-3155-4-4.
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Application of superparamagnetic iron oxide to imaging of hepatocellular carcinoma.超顺磁性氧化铁在肝细胞癌成像中的应用。
Eur J Radiol. 2006 May;58(2):200-16. doi: 10.1016/j.ejrad.2005.11.040. Epub 2006 Jan 18.
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Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector.具有表面修饰的磁性纳米颗粒增强了HVJ-E载体的基因递送。
Biochem Biophys Res Commun. 2005 Sep 9;334(4):1121-6. doi: 10.1016/j.bbrc.2005.06.204.
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Iron oxide nanoparticles for sustained delivery of anticancer agents.用于持续递送抗癌药物的氧化铁纳米颗粒。
Mol Pharm. 2005 May-Jun;2(3):194-205. doi: 10.1021/mp0500014.
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Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer.用于癌症诊断的抗表皮生长因子受体（EGFR）抗体偶联金纳米颗粒的表面等离子体共振散射和吸收：在口腔癌中的应用
Nano Lett. 2005 May;5(5):829-34. doi: 10.1021/nl050074e.
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Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging.通过体内磁共振成像进行检测的对干细胞和其他细胞进行磁性标记的方法。
Cytotherapy. 2004;6(6):621-5. doi: 10.1080/14653240410005267-1.
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Iron oxide MR contrast agents for molecular and cellular imaging.用于分子和细胞成像的氧化铁磁共振造影剂。
NMR Biomed. 2004 Nov;17(7):484-99. doi: 10.1002/nbm.924.
8
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.使用近红外吸收纳米颗粒对小鼠进行光热肿瘤消融。
Cancer Lett. 2004 Jun 25;209(2):171-6. doi: 10.1016/j.canlet.2004.02.004.
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Magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations.用于生物催化和生物分离的含磁铁矿球形二氧化硅纳米颗粒。
Anal Chem. 2004 Mar 1;76(5):1316-21. doi: 10.1021/ac034920m.
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Nanoshell-enabled photonics-based imaging and therapy of cancer.基于纳米壳的癌症光子成像与治疗
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具有超顺磁性氧化铁 - 二氧化硅核的双功能金纳米壳，适用于磁共振成像和光热疗法。

Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide-Silica Core Suitable for Both MR Imaging and Photothermal Therapy.

作者信息

Ji Xiaojun, Shao Ruping, Elliott Andrew M, Stafford R Jason, Esparza-Coss Emilio, Bankson James A, Liang Gan, Luo Zhi-Ping, Park Keeseong, Markert John T, Li Chun

机构信息

Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.

Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.

出版信息

J Phys Chem C Nanomater Interfaces. 2007 Apr 6;111(17):6245-6251. doi: 10.1021/jp0702245.

DOI:10.1021/jp0702245
PMID:20165552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2822349/
Abstract

We describe the synthesis, characterization, and use of hybrid nanoparticles with a superparamagnetic iron oxide (SPIO) core and a gold nanoshell. These multifunctional nanoparticles, designated SPIO-Au nanoshells, displayed superparamagnetic characteristics and a significant absorbance in the near-infrared (NIR) region of the electromagnetic spectrum. In addition, they exhibited high transverse relaxivity, , and a large ratio and therefore could be imaged by MRI to obtain T-weighted images. Moreover, SPIO-Au nanoshells showed efficient photo-thermal effect when exposed to NIR light. The use of SPIO-Au nanoshells, with their combination of unique magnetic and optical properties, should enhance the efficacy of nanoshell-mediated photo-thermal therapy by making it possible to direct more nanoparticles to tumors through the application of external magnetic field and by permitting real-time MRI imaging of the distribution of the nanoparticles before, during, and after photo-thermal therapy.

摘要

我们描述了具有超顺磁性氧化铁（SPIO）核心和金纳米壳的混合纳米颗粒的合成、表征及应用。这些多功能纳米颗粒，命名为SPIO-金纳米壳，表现出超顺磁性特性以及在电磁光谱近红外（NIR）区域有显著吸光度。此外，它们具有高横向弛豫率， ，以及大的 比，因此可通过磁共振成像（MRI）获得T加权图像。而且，SPIO-金纳米壳在近红外光照射下显示出高效的光热效应。SPIO-金纳米壳独特的磁性和光学特性相结合，通过施加外部磁场可将更多纳米颗粒导向肿瘤，并能在光热治疗前、治疗期间和治疗后对纳米颗粒分布进行实时MRI成像，有望提高纳米壳介导的光热治疗效果。