Mochizuki Chihiro, Nakamura Junna, Nakamura Michihiro
Department of Organ Anatomy & Nanomedicine, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
Core Clusters for Research Initiatives of Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
Biomedicines. 2021 Jan 13;9(1):73. doi: 10.3390/biomedicines9010073.
Nanoparticles have demonstrated several advantages for biomedical applications, including for the development of multifunctional agents as innovative medicine. Silica nanoparticles hold a special position among the various types of functional nanoparticles, due to their unique structural and functional properties. The recent development of silica nanoparticles has led to a new trend in light-based nanomedicines. The application of light provides many advantages for in vivo imaging and therapy of certain diseases, including cancer. Mesoporous and non-porous silica nanoparticles have high potential for light-based nanomedicine. Each silica nanoparticle has a unique structure, which incorporates various functions to utilize optical properties. Such advantages enable silica nanoparticles to perform powerful and advanced optical imaging, from the in vivo level to the nano and micro levels, using not only visible light but also near-infrared light. Furthermore, applications such as photodynamic therapy, in which a lesion site is specifically irradiated with light to treat it, have also been advancing. Silica nanoparticles have shown the potential to play important roles in the integration of light-based diagnostics and therapeutics, termed "photo-theranostics". Here, we review the recent development and progress of non-porous silica nanoparticles toward cancer "photo-theranostics".
纳米颗粒在生物医学应用中已展现出多种优势，包括用于开发多功能制剂作为创新药物。二氧化硅纳米颗粒在各类功能性纳米颗粒中占据特殊地位，这归因于其独特的结构和功能特性。二氧化硅纳米颗粒的最新进展引领了基于光的纳米医学的新趋势。光的应用为某些疾病（包括癌症）的体内成像和治疗带来诸多优势。介孔和无孔二氧化硅纳米颗粒在基于光的纳米医学中具有很高的潜力。每个二氧化硅纳米颗粒都有独特的结构，该结构整合了各种功能以利用光学特性。这些优势使二氧化硅纳米颗粒不仅能利用可见光，还能利用近红外光，在从体内水平到纳米和微观水平上进行强大而先进的光学成像。此外，诸如光动力疗法（通过特定照射病变部位进行治疗）等应用也在不断发展。二氧化硅纳米颗粒已显示出在基于光的诊断与治疗的整合（即“光诊疗”）中发挥重要作用的潜力。在此，我们综述无孔二氧化硅纳米颗粒在癌症“光诊疗”方面的最新进展。
