通过神经递质和芳香族氨基酸与氧形成活性氧诱导 DNA 断裂。
Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids.
机构信息
Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Yamada-oka 2-1, Suita, Osaka 565-0871, Japan.
出版信息
Org Biomol Chem. 2010 Mar 7;8(5):994-6. doi: 10.1039/b924560j. Epub 2010 Jan 18.
DOI:10.1039/b924560j
PMID:20165787
Abstract
UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.
摘要
紫外线-B 对神经递质（血清素）和芳香族氨基酸（色氨酸和酪氨酸）与氧气的光辐照会产生活性氧（ROS），从而导致 DNA 断裂，这一点通过 pBR 322 DNA 的琼脂糖凝胶电泳、ESR 和激光闪光光解测量得到了证明。
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