Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Bioorg Med Chem Lett. 2012 Jul 15;22(14):4668-71. doi: 10.1016/j.bmcl.2012.05.084. Epub 2012 May 30.
Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (≥350nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure.
合成了两种不同系列的萘和蒽基羟肟酸，它们都含有氨基酸衍生物。通过紫外线（≥350nm）照射新合成的羟肟酸，实现了单链 DNA 的断裂。结果表明，羟肟酸产生的活性氧（ROS）和自由基都参与了 DNA 的断裂。此外，羟肟酸的 DNA 断裂能力与其浓度及其结构有关。
