阴离子交换树脂存在下 BVMO 催化的外消旋苄基酮的动态动力学拆分。
BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins.
机构信息
Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006, Oviedo, Spain.
出版信息
Org Biomol Chem. 2010 Mar 7;8(5):1121-5. doi: 10.1039/b922693a. Epub 2010 Jan 7.
4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.
荧光假单胞菌 ACB 的 4-羟基苯乙酮单加氧酶在弱阴离子交换树脂的存在下，用于对映体苯乙酮进行动态动力学拆分，转化率高，光学纯度好。为了优化生物催化体系的活性和选择性，分析了影响酶促拜尔-维利格氧化和外消旋化效率的不同参数。
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