Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
Org Biomol Chem. 2010 Mar 7;8(5):1212-7. doi: 10.1039/b919325c. Epub 2010 Jan 13.
We developed a microflow method for the generation and reactions of aryllithiums bearing a cyano group, including o-lithiobenzonitrile, m-lithiobenzonitrile and p-lithiobenzonitrile. The method was effective at much higher temperatures than are required for conventional macrobatch reactions, by virtue of rapid mixing, short residence time, and efficient temperature control. In addition, reactions of o-lithiobenzonitrile with carbonyl compounds followed by trapping of the resulting lithium alkoxides with electrophiles were achieved in an integrated microflow system.
我们开发了一种用于生成和反应带有氰基的芳基锂的微流方法，包括邻位、间位和对位的苯甲腈锂。由于快速混合、短停留时间和高效的温度控制，该方法在比传统的宏批次反应所需的温度高得多的温度下仍然有效。此外，邻位苯甲腈锂与羰基化合物的反应，以及随后用亲电试剂捕获生成的锂烷氧基，都可以在集成的微流系统中实现。
