The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Org Lett. 2010 Mar 19;12(6):1224-7. doi: 10.1021/ol1000796.
The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings.
本文报道了四种新型高取代硅基芳基三氟甲磺酸酯芳基炔前体在芳基炔酰基烷基化、酰基烷基化/缩合和杂环化反应中完全区域选择性反应的情况。这些更复杂的芳基炔的应用为获得不同的天然产物骨架提供了途径，并避免了对芳环的后期官能化。
