Huang Yijuan, Zhao Hainan, Cao Kun, Sun Ding, Yang Yanyong, Liu Cong, Cui Jianguo, Cheng Ying, Li Bailong, Cai Jianming, Gao Fu
Department of Radiology, The First Hospital of Jiaxing, 1882 Zhonghuan South Road, Jiaxing, Zhejiang 314000, China.
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.
Oxid Med Cell Longev. 2016;2016:5706751. doi: 10.1155/2016/5706751. Epub 2016 Jun 26.
We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation. It is suggested that GSPs have a potential as an effective and safe radioprotective agent.
我们已经证明，葡萄籽原花青素（GSPs）能够以剂量依赖的方式有效清除羟基自由基（•OH）。由于大多数电离辐射（IR）诱导的损伤是由•OH引起的，本研究旨在探讨GSPs是否能在体外和体内减轻IR诱导的损伤。我们证明，GSPs可以显著减少IR诱导的人淋巴细胞AHH-1细胞的DNA链断裂（DSBs）和凋亡。本研究还表明，GSPs可以保护白细胞（WBC）免受IR诱导的损伤，加速小鼠体重恢复，并降低血浆丙二醛（MDA），从而提高小鼠在电离辐射后的存活率。提示GSPs有潜力成为一种有效且安全的辐射防护剂。
