Instituto de Biociências, Universidade de São Paulo, R. do Matão, Trav.14, n. 321, 05508-090, São Paulo, SP, Brazil.
Comp Biochem Physiol C Toxicol Pharmacol. 2010 May;151(4):461-6. doi: 10.1016/j.cbpc.2010.02.002. Epub 2010 Feb 16.
The effects of aluminum on plasma ion, lipid, protein and steroid hormone concentration were evaluated in Oreochromis niloticus broodstock females. Lipid and protein concentrations from the gonads and liver were also measured. Experiments were performed at neutral and acidic water pH. Four groups of fish were tested for 96h: 1) control conditions at neutral water pH; 2) control conditions at acidic water pH (CTR-Ac); 3) aluminum at neutral water pH (Al-N); and 4) aluminum at acidic water pH (Al-Ac). Aluminum and acidic water pH exposure caused no ionoregulatory disturbances. Total lipid concentration increased in the mature gonads and decreased in the liver, suggesting an acceleration of lipid mobilization to the ovaries in animals exposed to aluminum. However, a decreased protein concentration in ovaries was also observed. Exposure of control fish to acidic water pH caused an increased concentration of plasma 17alpha-hydroxyprogesterone. However, females exposed to aluminum at acidic water pH showed a decreased of plasma 17alpha-hydroxyprogesterone and cortisol. No differences in plasma 17beta-estradiol were observed. The physiological mechanisms underlying the disturbances observed are discussed focusing on reproduction. We suggest that aluminum can be considered an endocrine disrupting compound in mature O. niloticus females.
在奥利亚罗非鱼亲鱼雌性个体中评估了铝对血浆离子、脂质、蛋白质和类固醇激素浓度的影响。还测量了性腺和肝脏中的脂质和蛋白质浓度。实验在中性和酸性水 pH 值下进行。测试了 4 组鱼 96 小时：1）中性水 pH 值下的对照条件；2）酸性水 pH 值下的对照条件（CTR-Ac）；3）中性水 pH 值下的铝（Al-N）；和 4）酸性水 pH 值下的铝（Al-Ac）。铝和酸性水 pH 值暴露不会引起离子调节紊乱。总脂质浓度在成熟性腺中增加，在肝脏中减少，表明暴露于铝的动物中脂质向卵巢的动员加速。然而，还观察到卵巢中的蛋白质浓度降低。对照鱼暴露于酸性水 pH 值会导致血浆 17α-羟孕酮浓度增加。然而，在酸性水 pH 值下暴露于铝的雌性鱼类表现出血浆 17α-羟孕酮和皮质醇的减少。血浆 17β-雌二醇没有差异。讨论了观察到的干扰的生理机制，重点是繁殖。我们认为铝可以被认为是成熟奥利亚罗非鱼雌性个体中的内分泌干扰化合物。
