双亚型猫免疫缺陷病毒疫苗提供针对异源攻击的12个月保护性免疫。
Dual-subtype feline immunodeficiency virus vaccine provides 12 months of protective immunity against heterologous challenge.
作者信息
Huang Chengjin, Conlee Douglas, Gill Michael, Chu Hsien-Jue Steve
机构信息
Fort Dodge Animal Health Division of Wyeth, Fort Dodge, IA 50501, USA.
出版信息
J Feline Med Surg. 2010 Jun;12(6):451-7. doi: 10.1016/j.jfms.2009.12.016. Epub 2010 Feb 18.
Abstract
The duration of immunity of the dual-subtype feline immunodeficiency virus (FIV) vaccine, Fel-O-Vax FIV, for protection against subtype-B FIV was assessed in this study. Vaccinated cats along with controls were challenged with FIV(FC1), a subtype-B FIV strain, 54 weeks after the final vaccination, and monitored for 46-48 weeks for provirus and viral RNA in peripheral blood, provirus in lymphoid organs, and CD4:CD8 ratios. Results of provirus detection in peripheral blood and lymphoid organs and plasma viral RNA loads showed that 10/14 vaccinated cats were fully protected for 48 weeks against infection with FIV(FC1) whereas 5/5 controls were persistently infected with FIV(FC1). CD4:CD8 inversions were noted in association with FIV infection and viral loads were not significantly different between FIV infected controls and the unprotected vaccinated animals.
摘要
本研究评估了双亚型猫免疫缺陷病毒（FIV）疫苗Fel-O-Vax FIV针对B亚型FIV的免疫持续时间。在最后一次接种疫苗54周后，给接种疫苗的猫和对照猫用B亚型FIV毒株FIV(FC1)进行攻毒，并对外周血中的前病毒和病毒RNA、淋巴器官中的前病毒以及CD4:CD8比率进行了46 - 48周的监测。外周血和淋巴器官中前病毒检测结果以及血浆病毒RNA载量显示，14只接种疫苗的猫中有10只在48周内完全受到保护，未感染FIV(FC1)，而5只对照猫持续感染FIV(FC1)。FIV感染时出现了CD4:CD8倒置，FIV感染的对照猫和未受保护的接种动物之间的病毒载量无显著差异。
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