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Can Vet J. 2012 Jan;53(1):9-10; author reply 10.
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Feline leukemia virus and feline immunodeficiency virus in Canada: recommendations for testing and management.加拿大的猫白血病病毒和猫免疫缺陷病毒：检测与管理建议
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Important mammalian veterinary viral immunodiseases and their control.重要的哺乳动物兽医病毒性免疫病及其控制。
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本文引用的文献

1
Gag-specific immune enhancement of lentiviral infection after vaccination with an adenoviral vector in an animal model of AIDS.在艾滋病动物模型中，用腺病毒载体接种疫苗后，针对Gag的慢病毒感染免疫增强作用。
Vaccine. 2009 Feb 5;27(6):928-39. doi: 10.1016/j.vaccine.2008.11.086. Epub 2008 Dec 12.
2
Advances in FIV vaccine technology.猫免疫缺陷病毒疫苗技术的进展。
Vet Immunol Immunopathol. 2008 May 15;123(1-2):65-80. doi: 10.1016/j.vetimm.2008.01.030. Epub 2008 Jan 20.
3
Pathogenesis of a Texas feline immunodeficiency virus isolate: an emerging subtype of clade B.
Vet Microbiol. 2006 Jun 15;115(1-3):64-76. doi: 10.1016/j.vetmic.2006.02.012. Epub 2006 Mar 29.
4
Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity.北美猫群中猫白血病病毒和猫免疫缺陷病毒感染的血清流行率及血清阳性的风险因素。
J Am Vet Med Assoc. 2006 Feb 1;228(3):371-6. doi: 10.2460/javma.228.3.371.
5
Efficacy and safety of a feline immunodeficiency virus vaccine.一种猫免疫缺陷病毒疫苗的疗效与安全性。
Anim Health Res Rev. 2004 Dec;5(2):295-300. doi: 10.1079/ahr200487.
6
Dual-subtype vaccine (Fel-O-Vax FIV) protects cats against contact challenge with heterologous subtype B FIV infected cats.双亚型疫苗（Fel-O-Vax FIV）可保护猫免受与异源B亚型猫免疫缺陷病毒（FIV）感染猫接触性攻击。
Vet Microbiol. 2005 Jul 1;108(3-4):155-65. doi: 10.1016/j.vetmic.2005.02.014.
7
Dual-subtype FIV vaccine (Fel-O-Vax FIV) protection against a heterologous subtype B FIV isolate.双亚型猫免疫缺陷病毒疫苗（Fel-O-Vax FIV）对异源B亚型猫免疫缺陷病毒分离株的保护作用。
J Feline Med Surg. 2005 Feb;7(1):65-70. doi: 10.1016/j.jfms.2004.08.005.
8
Cellular immune responses to feline immunodeficiency virus (FIV) induced by dual-subtype FIV vaccine.双亚型猫免疫缺陷病毒（FIV）疫苗诱导的针对猫免疫缺陷病毒（FIV）的细胞免疫反应。
Vaccine. 2004 Dec 2;23(3):386-98. doi: 10.1016/j.vaccine.2004.05.032.
9
Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics.中欧猫免疫缺陷病毒的系统发育分析：疫苗接种和分子诊断的前提条件
J Gen Virol. 2003 May;84(Pt 5):1301-1307. doi: 10.1099/vir.0.18736-0.
10
Dual-subtype FIV vaccine protects cats against in vivo swarms of both homologous and heterologous subtype FIV isolates.双亚型猫免疫缺陷病毒疫苗可保护猫抵御同源和异源猫免疫缺陷病毒分离株在体内的群聚感染。
AIDS. 2001 Jul 6;15(10):1225-37. doi: 10.1097/00002030-200107060-00004.

双亚型猫免疫缺陷病毒疫苗提供针对异源攻击的12个月保护性免疫。

Dual-subtype feline immunodeficiency virus vaccine provides 12 months of protective immunity against heterologous challenge.

作者信息

Huang Chengjin, Conlee Douglas, Gill Michael, Chu Hsien-Jue Steve

机构信息

Fort Dodge Animal Health Division of Wyeth, Fort Dodge, IA 50501, USA.

出版信息

J Feline Med Surg. 2010 Jun;12(6):451-7. doi: 10.1016/j.jfms.2009.12.016. Epub 2010 Feb 18.

DOI:10.1016/j.jfms.2009.12.016
PMID:20167521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10822280/
Abstract

The duration of immunity of the dual-subtype feline immunodeficiency virus (FIV) vaccine, Fel-O-Vax FIV, for protection against subtype-B FIV was assessed in this study. Vaccinated cats along with controls were challenged with FIV(FC1), a subtype-B FIV strain, 54 weeks after the final vaccination, and monitored for 46-48 weeks for provirus and viral RNA in peripheral blood, provirus in lymphoid organs, and CD4:CD8 ratios. Results of provirus detection in peripheral blood and lymphoid organs and plasma viral RNA loads showed that 10/14 vaccinated cats were fully protected for 48 weeks against infection with FIV(FC1) whereas 5/5 controls were persistently infected with FIV(FC1). CD4:CD8 inversions were noted in association with FIV infection and viral loads were not significantly different between FIV infected controls and the unprotected vaccinated animals.

摘要

本研究评估了双亚型猫免疫缺陷病毒（FIV）疫苗Fel-O-Vax FIV针对B亚型FIV的免疫持续时间。在最后一次接种疫苗54周后，给接种疫苗的猫和对照猫用B亚型FIV毒株FIV(FC1)进行攻毒，并对外周血中的前病毒和病毒RNA、淋巴器官中的前病毒以及CD4:CD8比率进行了46 - 48周的监测。外周血和淋巴器官中前病毒检测结果以及血浆病毒RNA载量显示，14只接种疫苗的猫中有10只在48周内完全受到保护，未感染FIV(FC1)，而5只对照猫持续感染FIV(FC1)。FIV感染时出现了CD4:CD8倒置，FIV感染的对照猫和未受保护的接种动物之间的病毒载量无显著差异。