Kelly Kevin, Storey Lorna, O' Sullivan Maureen, Butler Karina, McDermott Michael, Corbally Martin, McMahon Corrina, Smith Owen P, O' Marcaigh Aengus
Departments of Haematology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
J Pediatr Hematol Oncol. 2010 Mar;32(2):124-7. doi: 10.1097/MPH.0b013e3181ced25c.
Esophageal stricture is a rare complication of paediatric cancer treatment that usually occurs after esophageal exposure to radiotherapy. We describe 4 cases of esophageal stricture during chemotherapy for acute lymphoblastic leukemia. All patients presented with refractory vomiting and were diagnosed with radiologic contrast studies. None of the patients had received radiotherapy. Esophageal candidiasis was seen in 2 patients but the remaining 2 patients had earlier systemic candidiasis. High-dose dexamethasone may predispose these children to both esophageal candidiasis and peptic esophagitis. The etiology of esophageal strictures during treatment for acute leukemia is likely to be multifactorial but systemic candidiasis may play a significant role.
食管狭窄是儿童癌症治疗中一种罕见的并发症，通常发生在食管接受放疗之后。我们描述了4例急性淋巴细胞白血病化疗期间出现食管狭窄的病例。所有患者均表现为难治性呕吐，并通过放射学造影检查确诊。所有患者均未接受过放疗。2例患者出现食管念珠菌病，其余2例患者此前有全身性念珠菌病。高剂量地塞米松可能使这些儿童易患食管念珠菌病和消化性食管炎。急性白血病治疗期间食管狭窄的病因可能是多因素的，但全身性念珠菌病可能起重要作用。
