Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, USA.
Obesity (Silver Spring). 2010 Sep;18(9):1861-3. doi: 10.1038/oby.2010.24. Epub 2010 Feb 18.
The incidence of obesity, insulin resistance, and type 2 diabetes (T2D) is increasing at an alarming rate worldwide. Emerging experimental evidence suggests that the hormone melatonin plays an important role in the regulation of glucose metabolisms. In this study, we report that removal of melatonin receptor type 1 (MT1) significantly impairs the ability of mice to metabolize glucose and such inability is probably due to an increased insulin resistance in these mice. Our data suggest that MT1 receptors are implicated in the pathogenesis of T2D and open the door for a detailed exploration on the mechanisms by which MT1 receptors signaling may affect glucose metabolism.
肥胖症、胰岛素抵抗和 2 型糖尿病（T2D）的发病率在全球呈惊人的速度上升。新出现的实验证据表明，激素褪黑素在调节葡萄糖代谢方面起着重要作用。在这项研究中，我们报告说，褪黑素受体 1（MT1）的去除显著损害了小鼠代谢葡萄糖的能力，而这种无能可能是由于这些小鼠的胰岛素抵抗增加所致。我们的数据表明，MT1 受体与 T2D 的发病机制有关，并为详细探讨 MT1 受体信号可能影响葡萄糖代谢的机制打开了大门。
