Endoscopy Unit & Inflammatory Bowel Diseases Unit, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis 68100, Greece.
Gastroenterol Res Pract. 2009;2009:924138. doi: 10.1155/2009/924138. Epub 2010 Feb 11.
The objective is the investigation of Joint Hypermobility (JH) and the Hypermobility Syndrome (HMS) in patients with inflammatory bowel disease (IBD).
We examined 83 patients with IBD and 67 healthy individuals for the presence of JH. Patients were excluded if they were under 18 or over 50 years of age and if they had other conditions which affect joint mobility. The x(2) and the Fisher exact test were used appropriately between study groups. Odds ratios (ORs) for the risk of JH and HMS in IBD groups were calculated.
A total of 150 individuals (83 IBD patients and 67 healthy controls) participated in the study. 69 IBD patients, 41 with Crohn's Disease (CD) and 28 with ulcerative colitis (UC), were finally eligible. JH was detected in 29 CD patients (70.7%), in 10 UC patients (35.7%), and in 17 healthy control subjects (25.4%). Significant difference was detected on JH in CD patients as compared to UC patients (P = .0063) and controls (P < .0001). The estimated OR for JH was 7.108 (95% CI: 2.98-16.95) in CD and 1.634 (95% CI: 0.63-4.22) in UC patients. HMS was detected in 5 (12.2%) CD and in 1 (3.57%) UC patients. The OR for HMS in CD was 3.75 (95% CI: 0.41-34.007), while 7 (17.1%) CD patients had overlapping symptoms for both HMS and early spondylarthropathy.
JH and the HMS are common in CD patients, thus articular manifestations should be carefully interpreted. This implies an involvement of collagen varieties in the pathogenesis of IBD.
本研究旨在调查炎症性肠病（IBD）患者的关节过度活动（JH）和过度活动综合征（HMS）。
我们检查了 83 例 IBD 患者和 67 名健康对照者的 JH 情况。如果患者年龄小于 18 岁或大于 50 岁，或者患有其他影响关节活动度的疾病，则将其排除在外。在研究组之间适当使用 x(2)检验和 Fisher 确切检验。计算 IBD 组 JH 和 HMS 的风险的比值比（OR）。
共有 150 人（83 例 IBD 患者和 67 名健康对照者）参与了研究。最终有 69 例 IBD 患者，41 例克罗恩病（CD）和 28 例溃疡性结肠炎（UC）符合条件。在 29 例 CD 患者（70.7%）、10 例 UC 患者（35.7%）和 17 例健康对照者（25.4%）中检测到 JH。与 UC 患者（P =.0063）和对照组（P <.0001）相比，CD 患者的 JH 差异有统计学意义。CD 患者 JH 的估计 OR 为 7.108（95%CI：2.98-16.95），UC 患者为 1.634（95%CI：0.63-4.22）。在 5 例 CD（12.2%）和 1 例 UC（3.57%）患者中检测到 HMS。CD 患者 HMS 的 OR 为 3.75（95%CI：0.41-34.007），而 7 例（17.1%）CD 患者 HMS 和早期脊柱关节病的症状重叠。
JH 和 HMS 在 CD 患者中很常见，因此应仔细解释关节表现。这意味着胶原蛋白种类可能参与了 IBD 的发病机制。
