Chen Y H, Wang J Y, Zhou S, Shoyab M
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing.
Life Sci. 1991;48(17):PL79-83. doi: 10.1016/0024-3205(91)90129-y.
This paper describes the influence of bovine endozepine (BEP) on the analgesic effect of morphine. The intraventricular administration of BEP between doses of 2-4 nmole in mice resulted in the potentiation of the morphine-analgesic effect. The basic pain threshold did not change when BEP was given alone, thus indicating that BEP is unable to elicit analgesic effect alone. Intravenous injection of BEP in the dose range of 5-7.5 mg/kg also potentiated the analgesic effect of morphine. These observations suggest that endozepine can act as a regulator of pain.
本文描述了牛内啡肽（BEP）对吗啡镇痛作用的影响。给小鼠脑室内注射2-4纳摩尔剂量的BEP，可增强吗啡的镇痛作用。单独给予BEP时，基础痛阈未发生变化，这表明BEP本身不能产生镇痛作用。静脉注射5-7.5毫克/千克剂量范围的BEP也可增强吗啡的镇痛作用。这些观察结果表明，内啡肽可作为疼痛的调节剂。
