Fujiwara Kumiko
Department of Anesthesiology, Showa University, School of Medicine, Tokyo 142-8555.
Masui. 2010 Feb;59(2):169-78.
Preoperative lung function tests are useful to evaluate the preoperative pulmonary condition and to detect a high risk of postoperative pulmonary complications. However, maximum expiratory effort by patients is necessary to determine lung function using spirometry and flow-volume curve measurements. When patients are not able to expire completely during the measurement, incorrect data regarding their respiratory system is obtained. On the other hand, respiratory system impedance using an impulse oscillatory system (IOS) can evaluate total airway resistance (R5), large airway resistance (R20), small airway resistance (R5-20) and reactance (X5) under breathing at rest within a few minutes. There are few reports that indicate the standard values for IOS. In addition, the effects of age on IOS value are not clear. In this study preoperative lung functions using IOS were studied to examine the standard value and effect of aging.
Subjects were 420 patients aged from 20 to 89 years with normal pulmonary function (%VC > or = 80%, %FEV(1.0) > or = 70%), and scheduled for an elective surgery. Lung function measurements such as IOS, spirometry, maximum expiratory flow-volume curve and single N2 washout were done preoperatively. Subjects were divided into seven groups in decades from 20 to 80.
Although there was no statistical change in R5, R20, R5-R20, Z5 and X5 in the decades from 20 to 60, there were statistically significant changes during the 70s and 80s. There were significant differences in IOS parameters between the adult group and the aged group. Changes due to aging were stronger on V25/Ht than those of IOS.
This study indicates that there are differences between V25/Ht and IOS values because of the difference in breathing conditions during measurements.
术前肺功能测试有助于评估术前肺部状况并检测术后肺部并发症的高风险。然而,使用肺活量计和流量 - 容积曲线测量来确定肺功能时,患者需要进行最大呼气努力。当患者在测量过程中无法完全呼气时,会获得有关其呼吸系统的错误数据。另一方面,使用脉冲振荡系统(IOS)的呼吸系统阻抗可以在几分钟内评估静息呼吸时的总气道阻力(R5)、大气道阻力(R20)、小气道阻力(R5 - 20)和电抗(X5)。很少有报告指出IOS的标准值。此外,年龄对IOS值的影响尚不清楚。在本研究中,使用IOS对术前肺功能进行研究,以检查标准值和衰老的影响。
研究对象为420例年龄在20至89岁之间、肺功能正常(%VC≥80%,%FEV(1.0)≥70%)且计划进行择期手术的患者。术前进行了IOS、肺活量计、最大呼气流量 - 容积曲线和单次氮洗脱等肺功能测量。受试者按十年分为七组,年龄从20岁到80岁。
虽然在20至60岁的十年间,R5、R20、R5 - R20、Z5和X5没有统计学上的变化,但在70岁和80岁期间有统计学上的显著变化。成人组和老年组之间的IOS参数存在显著差异。衰老导致的变化在V25/Ht上比在IOS上更强。
本研究表明,由于测量过程中呼吸条件的差异,V25/Ht和IOS值之间存在差异。