Sugimoto Y, Kimura I, Yamada J, Watanabe Y, Takeuchi N, Horisaka K
Department of Pharmacology Kobe Women's College of Pharmacy, Japan.
Jpn J Pharmacol. 1990 Sep;54(1):93-6. doi: 10.1254/jjp.54.93.
Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neither the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.
在小鼠中研究了血清素（5-羟色胺，5-HT）对血糖和血清胰岛素水平的影响。在正常小鼠中，5-HT诱导剂量依赖性低血糖并使血清胰岛素水平升高。5-HT显著抑制葡萄糖诱导的高血糖症并增加葡萄糖刺激的胰岛素释放。然而，在链脲佐菌素诱导的糖尿病小鼠中，5-HT既未改变血糖水平也未改变胰岛素水平。这些结果有力地表明，5-HT诱导的低血糖是由血清胰岛素水平升高引起的。
