Marubashi S, Kunii Y, Tominaga M, Sasaki H
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Neuroendocrinology. 1988 Dec;48(6):640-4. doi: 10.1159/000125075.
Thyrotropin-releasing hormone (TRH), but not histidyl-proline diketopiperazine (cyclo[His-Pro]), induced transient hyperglycemia associated with hyperglucagonemia and marked hyperinsulinemia when placed intracerebroventricularly (i.c.v.) in anesthetized rats. This TRH-induced hyperglycemia was prevented by acute adrenalectomy. However, adrenalectomy did not prevent TRH-induced hyperinsulinemia or hyperglucagonemia. In streptozotocin-induced diabetic rats, i.c.v. administration of TRH caused progressive and pronounced hyperglycemia. i.c.v. TRH-induced hyperinsulinemia was abolished by vagotomy and by systemic administration of hexamethonium or atropine. These results suggest that TRH induces hyperglycemia mediated by stimulation of the sympathetico-adrenal system and hyperinsulinemia by stimulation of the vagus nerve, and that the rapid decline of plasma glucose levels following transient hyperglycemia is due to hyperinsulinemia.
将促甲状腺激素释放激素（TRH）而非组氨酰 - 脯氨酸二酮哌嗪（环[His - Pro]）经脑室内（i.c.v.）注射到麻醉大鼠体内时，会引发短暂性高血糖，并伴有高胰高血糖素血症和显著的高胰岛素血症。急性肾上腺切除可预防这种由TRH诱导的高血糖。然而，肾上腺切除并不能预防TRH诱导的高胰岛素血症或高胰高血糖素血症。在链脲佐菌素诱导的糖尿病大鼠中，经脑室内注射TRH会导致进行性且明显的高血糖。经脑室内注射TRH诱导的高胰岛素血症可通过迷走神经切断术以及全身给予六甲铵或阿托品而消除。这些结果表明，TRH通过刺激交感 - 肾上腺系统诱导高血糖，通过刺激迷走神经诱导高胰岛素血症，并且短暂性高血糖后血浆葡萄糖水平的快速下降是由于高胰岛素血症所致。
