School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
J Org Chem. 2010 Mar 19;75(6):2085-8. doi: 10.1021/jo9026879.
A very simple, efficient, and regiospecific protocol for aminobromination of a wide scope of beta-nitrostyrene derivatives with N-bromoacetamide (NBA) as nitrogen/bromine sources has been developed by using K(3)PO(4) as catalyst. The reaction proceeded smoothly and cleanly to give the bromoamines in good to excellent yields (78-99%) within 24 h in CH(2)Cl(2) at room temperature without protection of inert gases. A possible mechanism involving a nucleophilic conjugate addition was proposed.
我们开发了一种非常简单、高效和区域选择性的方法，使用 K(3)PO(4)作为催化剂，以 N-溴代乙酰胺（NBA）作为氮/溴源，对广泛范围的β-硝基苯乙烯衍生物进行氨基溴化。该反应在室温下在 CH(2)Cl(2)中顺利进行，无需惰性气体保护，24 小时内即可得到良好至优秀的溴代胺收率（78-99%）。提出了一种可能的涉及亲核共轭加成的机制。
