Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, Brazil.
J Med Food. 2010 Apr;13(2):348-51. doi: 10.1089/jmf.2009.0099.
Bowdichia virgilioides Kunth (Family Fabaceae) is a plant that is distributed widely in the tropical and subtropical regions of the world. In the northeast region of Brazil, where B. virgilioides is called "sucupira-preta," the stem bark is used in folk medicine to treatment of inflammatory and painful diseases. This study aimed to evaluate the antinociceptive activity of the aqueous extract of the dried stem bark of B. virgilioides. The aqueous extract of B. virgilioides in doses of 50, 100, 200, and 400 mg/kg was administered orally 1 hour prior to pain induction. Only the doses of 200 and 400 mg/kg produced an inhibition by 61% and 74%, respectively, in the number of abdominal writhings induced by acetic acid. This antinociceptive effect was not reversed by pretreatment with naloxone, indicating that the effect is not associated with the activation of opioid receptors. In the formalin test, using the two highest doses, the extract had no effect in the first phase but produced an analgesic effect on the second phase with the inhibition of licking time (P < .001). In the hot plate test, no effect was seen at the dose of 400 mg/kg p.o. Our findings show that B. virgilioides contains pharmacologically active constituents that possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions.
弓果藤（茜草科）是一种广泛分布于世界热带和亚热带地区的植物。在巴西东北部，弓果藤被称为“sucupira-preta”，其茎皮被民间医学用于治疗炎症和疼痛性疾病。本研究旨在评估弓果藤干茎皮水提物的镇痛活性。将弓果藤水提物以 50、100、200 和 400 mg/kg 的剂量口服给药，在疼痛诱导前 1 小时给药。只有 200 和 400 mg/kg 的剂量分别使醋酸诱导的腹部扭曲次数减少了 61%和 74%。这种镇痛作用不能被纳洛酮预处理逆转，表明该作用与阿片受体的激活无关。在福马林试验中，使用两个最高剂量，提取物在第一阶段没有作用，但在第二阶段产生镇痛作用，减少舔舐时间（P<0.001）。在热板试验中，400 mg/kg po 剂量没有效果。我们的研究结果表明，弓果藤含有具有镇痛活性的药理活性成分，证明其在治疗与疼痛相关的疾病方面的民间应用是合理的。
