Barros Wander M, Rao Vietla S N, Silva Regilane M, Lima Joaquim C S, Martins Domingos T O
Departamento de Ciências Básicas em Saúde, FCM, Universidade Federal de Mato Grosso, Boa Esperança, Campus Universitário, Cuiabá, MT, Brazil.
An Acad Bras Cienc. 2010 Sep;82(3):609-16. doi: 10.1590/s0001-37652010000300008.
Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.
维吉尼亚鲍迪豆（Bowdichia virgilioides H.B.K）的茎皮（豆科），当地称为“黑苏库皮拉”，是一种治疗某些炎症性疾病的著名民间药物。为了验证其传统功效，对维吉尼亚鲍迪豆的乙醇提取物在几种炎症和痛觉过敏动物模型中进行了评估。口服剂量为100至1000毫克/千克体重的提取物可显著抑制角叉菜胶诱导的后爪水肿，抑制角叉菜胶诱导的大鼠胸膜炎中的渗出液体积和白细胞迁移，并减轻棉球促进的皮下肉芽肿模型中的肉芽肿重量。此外，该植物提取物可显著抑制腹腔注射乙酸引起的血管通透性增加。它在乙酸诱导的扭体试验和小鼠福尔马林试验的第二阶段也显示出明显的镇痛作用。这些发现证明了维吉尼亚鲍迪豆树皮的抗炎潜力，并支持其在炎症性疾病中的传统用途。
