Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, Petrolina, Pernambuco 56.304-205, Brazil.
BMC Complement Altern Med. 2012 Oct 19;12:187. doi: 10.1186/1472-6882-12-187.
Selaginella convoluta (Arn.) Spring (Selaginellaceae), commonly known as "jericó", is a medicinal plant found in northeastern Brazil. S. convoluta is used in folk medicine as an antidepressant, aphrodisiac, diuretic, analgesic, anti-inflammatory and it is used to combat amenorrhea, coughing and bleeding. This study was performed to evaluate the antinociceptive effects of ethanolic extract from S. convoluta in mice exposed to chemical and thermal models of nociception.
Preliminary phytochemical analysis of the ethanolic extract was performed. The ethanolic extract from Selaginella convoluta (Sc-EtOH) was examined for its intraperitoneal (i.p.) antinociceptive activity at the doses of 100, 200 and 400 mg/kg body weight. Acetic acid-induced writhing, formalin injection and hot plate tests were used to evaluate the antinociceptive activity of Sc-EtOH extract. The rota-rod test was used to evaluate motor coordination.
A preliminary analysis of Sc-EtOH revealed that it contained phenols, steroids, terpenoids and flavonoids. In the acetic acid-induced writhing test, mice treated with Sc-EtOH (100, 200 and 400 mg/kg, i.p.) exhibited reduced writhing (58.46, 75.63 and 82.23%, respectively). Secondly, Sc-EtOH treatment (100, 200 and 400 mg/kg, i.p.) decreased the paw licking time in mice during the first phase of the formalin test (by 44.90, 33.33 and 34.16%, respectively), as well as during the second phase of the test (by 86.44, 56.20 and 94.95%, respectively). Additionally, Sc-EtOH treatment at doses of 200 and 400 mg/kg increased the latency time in the hot plate test after 60 and 90 minutes, respectively. In addition, Sc-EtOH did not impair motor coordination.
Overall, these results indicate that Sc-EtOH is effective as an analgesic agent in various pain models. The activity of Sc-EtOH is most likely mediated via the inhibition of peripheral mediators and central inhibitory mechanisms. This study supports previous claims of traditional uses for S. convoluta.
卷柏（Selaginella convoluta（Arn.）Spring），俗称“jericó”，是一种在巴西东北部发现的药用植物。在民间医学中，卷柏被用作抗抑郁药、壮阳药、利尿剂、镇痛药、消炎药，用于治疗闭经、咳嗽和出血。本研究旨在评估卷柏乙醇提取物在化学和热痛觉模型中对小鼠的镇痛作用。
对乙醇提取物进行了初步的植物化学分析。以 100、200 和 400mg/kg 体重的剂量腹腔注射（i.p.）卷柏乙醇提取物（Sc-EtOH），观察其镇痛活性。采用醋酸扭体、福尔马林注射和热板试验评价 Sc-EtOH 提取物的镇痛活性。旋转棒试验用于评估运动协调能力。
Sc-EtOH 的初步分析表明，它含有酚类、甾体、萜类和类黄酮。在醋酸扭体试验中，用 Sc-EtOH（100、200 和 400mg/kg，i.p.）治疗的小鼠扭体次数减少（分别为 58.46%、75.63%和 82.23%）。其次，Sc-EtOH 处理（100、200 和 400mg/kg，i.p.）降低了福尔马林试验第一阶段中小鼠的舔爪时间（分别为 44.90%、33.33%和 34.16%）和第二阶段（分别为 86.44%、56.20%和 94.95%）。此外，Sc-EtOH 处理剂量为 200 和 400mg/kg 时，分别在 60 和 90 分钟后增加了热板试验的潜伏期。此外，Sc-EtOH 不损害运动协调能力。
综上所述，这些结果表明 Sc-EtOH 对各种疼痛模型具有镇痛作用。Sc-EtOH 的活性可能是通过抑制外周介质和中枢抑制机制介导的。本研究支持了卷柏传统用途的说法。
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